WFDC5

WAP four-disulfide core domain protein 5 is a protein that in humans is encoded by the WFDC5 gene.[5][6][7]

WFDC5
Identifiers
Aliases	WFDC5, PRG5, WAP1, dJ211D12.5, WAP four-disulfide core domain 5
External IDs	OMIM: 605161 MGI: 2384800 HomoloGene: 17072 GeneCards: WFDC5
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,109,452 bp[1] End 45,115,172 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 164,176,327 bp[2] End 164,182,742 bp[2]
Gene ontology Molecular function • peptidase inhibitor activity • serine-type endopeptidase inhibitor activity Cellular component • extracellular region Biological process • negative regulation of endopeptidase activity • negative regulation of peptidase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	149708	209232
Ensembl	ENSG00000175121	ENSMUSG00000040154
UniProt	Q8TCV5	n/a
RefSeq (mRNA)	NM_145652	NM_145369
RefSeq (protein)	NP_663627	n/a
Location (UCSC)	Chr 20: 45.11 – 45.12 Mb	Chr 2: 164.18 – 164.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000175121 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040154 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Clauss A, Lilja H, Lundwall A (Nov 2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein". Biochem J. 368 (Pt 1): 233–42. doi:10.1042/BJ20020869. PMC 1222987. PMID 12206714.
6. Ranganathan S, Simpson KJ, Shaw DC, Nicholas KR (Mar 2000). "The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling". J Mol Graph Model. 17 (2): 106–13, 134–6. doi:10.1016/S1093-3263(99)00023-6. PMID 10680116.
7. "Entrez Gene: WFDC5 WAP four-disulfide core domain 5".

Further reading

• Horikoshi N, Cong J, Kley N, Shenk T (1999). "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene". Biochem. Biophys. Res. Commun. 261 (3): 864–9. doi:10.1006/bbrc.1999.1123. PMID 10441517.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nukumi N, Seki M, Iwamori T, et al. (2006). "Analysis of the promoter of mutated human whey acidic protein (WAP) gene". J. Reprod. Dev. 52 (2): 315–20. doi:10.1262/jrd.17068. PMID 16462094.
• Mukhopadhyay SS, Rosen JM (2007). "The C-terminal domain of the Nuclear Factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells". Biochem. Biophys. Res. Commun. 358 (3): 770–6. doi:10.1016/j.bbrc.2007.04.185. PMC 1942171. PMID 17511965.