WIPI1

WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40 repeat protein interacting with phosphoinositides of 49 kDa (WIPI 49 kDa), is a protein that in humans is encoded by the WIPI1 gene.[4][5][6]

WIPI1
Identifiers
Aliases	WIPI1, ATG18, ATG18A, WIPI49, WD repeat domain, phosphoinositide interacting 1
External IDs	OMIM: 609224 MGI: 1261864 HomoloGene: 117983 GeneCards: WIPI1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q24.2 Start 68,420,948 bp[1] End 68,457,513 bp[1]
Gene ontology Molecular function • phosphatidylinositol-3-phosphate binding • phosphatidylinositol-3,5-bisphosphate binding • androgen receptor binding • receptor binding • estrogen receptor binding • GO:0001948 protein binding • lipid binding Cellular component • cytoplasm • pre-autophagosomal structure membrane • endosome • Golgi apparatus • membrane • Golgi membrane • trans-Golgi network • autophagosome membrane • endosome membrane • cytoskeleton • cytoplasmic vesicle • clathrin-coated vesicle • pre-autophagosomal structure • cytosol • extrinsic component of membrane Biological process • vesicle targeting, trans-Golgi to endosome • autophagy • IRE1-mediated unfolded protein response • macroautophagy • mitophagy • protein lipidation • protein localization to pre-autophagosomal structure • autophagy of nucleus • autophagosome assembly • cellular response to starvation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55062	52639
Ensembl	ENSG00000070540	ENSMUSG00000041895
UniProt	Q5MNZ9	Q8R3E3
RefSeq (mRNA)	NM_017983 NM_001320772	NM_145940
RefSeq (protein)	NP_001307701 NP_060453	NP_666052
Location (UCSC)	Chr 17: 68.42 – 68.46 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Structure and function

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein–protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids.[4][6]

See also

• WIPI protein family

References

1. GRCh38: Ensembl release 89: ENSG00000070540 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: WD repeat domain".
5. Jeffries TR, Dove SK, Michell RH, Parker PJ (June 2004). "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49". Mol. Biol. Cell. 15 (6): 2652–63. doi:10.1091/mbc.E03-10-0732. PMC 420090. PMID 15020712.
6. Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A (December 2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573.

Further reading

• Chasman DI, Paré G, Mora S, Hopewell JC, Peloso G, Clarke R, Cupples LA, Hamsten A, Kathiresan S, Mälarstig A, Ordovas JM, Ripatti S, Parker AN, Miletich JP, Ridker PM (November 2009). "Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis". PLOS Genet. 5 (11): e1000730. doi:10.1371/journal.pgen.1000730. PMC 2777390. PMID 19936222.
• Behrends C, Sowa ME, Gygi SP, Harper JW (July 2010). "Network organization of the human autophagy system". Nature. 466 (7302): 68–76. doi:10.1038/nature09204. PMC 2901998. PMID 20562859.
• Proikas-Cezanne T, Ruckerbauer S, Stierhof YD, Berg C, Nordheim A (July 2007). "Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy". FEBS Lett. 581 (18): 3396–404. doi:10.1016/j.febslet.2007.06.040. PMID 17618624. S2CID 23430881.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.