WNK2

Serine/threonine-protein kinase WNK2 is an enzyme that in humans is encoded by the WNK2 gene.[5][6][7]

WNK2
Identifiers
Aliases	WNK2, NY-CO-43, P/OKcl.13, PRKSDCCAG43, WNK lysine deficient protein kinase 2
External IDs	OMIM: 606249 MGI: 1922857 HomoloGene: 19155 GeneCards: WNK2
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.31 Start 93,184,916 bp[1] End 93,320,572 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A5|13 25.07 cM Start 49,036,303 bp[2] End 49,148,014 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • ATP binding • kinase activity • protein serine/threonine kinase activity • chloride channel inhibitor activity • potassium channel inhibitor activity Cellular component • cytoplasm • cell membrane • membrane • cytosol Biological process • negative regulation of ERK1 and ERK2 cascade • autophosphorylation • protein phosphorylation • positive regulation of sodium ion transmembrane transporter activity • GO:0007243 intracellular signal transduction • phosphorylation • negative regulation of cell proliferation • positive regulation of canonical Wnt signaling pathway • ion homeostasis • negative regulation of sodium ion transport • positive regulation of ion transmembrane transporter activity • positive regulation of potassium ion import Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	65268	75607
Ensembl	ENSG00000165238	ENSMUSG00000037989
UniProt	Q9Y3S1	Q3UH66
RefSeq (mRNA)	NM_001282394 NM_006648	NM_001290311 NM_001290313 NM_029361
RefSeq (protein)	NP_001269323 NP_006639	NP_001277240 NP_001277242 NP_083637
Location (UCSC)	Chr 9: 93.18 – 93.32 Mb	Chr 13: 49.04 – 49.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000165238 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037989 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ (Jun 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int J Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
6. Verissimo F, Jordan P (Sep 2001). "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms". Oncogene. 20 (39): 5562–9. doi:10.1038/sj.onc.1204726. PMID 11571656.
7. "Entrez Gene: WNK2 WNK lysine deficient protein kinase 2".

Further reading

• Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Ito M, Shichijo S, Tsuda N, et al. (2001). "Molecular basis of T cell-mediated recognition of pancreatic cancer cells". Cancer Res. 61 (5): 2038–46. PMID 11280764.
• Wilson FH, Disse-Nicodème S, Choate KA, et al. (2001). "Human hypertension caused by mutations in WNK kinases". Science. 293 (5532): 1107–12. doi:10.1126/science.1062844. PMID 11498583. S2CID 22700809.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Moniz S, Veríssimo F, Matos P, et al. (2007). "Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2". Oncogene. 26 (41): 6071–81. doi:10.1038/sj.onc.1210706. PMID 17667937.