WRNIP1

ATPase WRNIP1 is an enzyme that in humans is encoded by the WRNIP1 gene.[5][6] The protein is a member of AAA ATPase family.

WRNIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VHS, 3VHT
Identifiers
Aliases	WRNIP1, WHIP, bA420G6.2, Werner helicase interacting protein 1, WRN helicase interacting protein 1, CFAP93, FAP93
External IDs	OMIM: 608196 MGI: 1926153 HomoloGene: 10592 GeneCards: WRNIP1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p25.2 Start 2,765,393 bp[1] End 2,786,952 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.2 Start 32,802,038 bp[2] End 32,822,609 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • nucleotide binding • ATPase activity • GO:0001948 protein binding • hydrolase activity • ATP binding • metal ion binding • identical protein binding • GO:0010577 enzyme activator activity • GO:0043142 single-stranded DNA helicase activity Cellular component • perinuclear region of cytoplasm • membrane • cell nucleus • nuclear chromosome, telomeric region • cytoplasm • replisome Biological process • DNA replication • DNA synthesis involved in DNA repair • regulation of DNA-dependent DNA replication initiation • DNA repair • cellular response to DNA damage stimulus • DNA strand renaturation • immune system process • DNA-dependent DNA replication • regulation of DNA repair • DNA recombination • DNA replication, Okazaki fragment processing • GO:0048554 positive regulation of catalytic activity • innate immune system Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56897	78903
Ensembl	ENSG00000124535	ENSMUSG00000021400
UniProt	Q96S55	Q91XU0
RefSeq (mRNA)	NM_020135 NM_130395	NM_030215
RefSeq (protein)	NP_064520 NP_569079	NP_084491
Location (UCSC)	Chr 6: 2.77 – 2.79 Mb	Chr 13: 32.8 – 32.82 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Werner's syndrome is a rare autosomal recessive disorder characterized by premature aging. The protein encoded by this gene interacts with the N-terminal portion of Werner protein containing the exonuclease domain. This protein shows homology to replication factor C family proteins, and is conserved from E. coli to human. Studies in yeast suggest that this gene may influence the aging process. Two transcript variants encoding different isoforms have been isolated for this gene.[6]

Interactions

WRNIP1 has been shown to interact with Werner syndrome ATP-dependent helicase.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000124535 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021400 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kawabe Yi, Branzei D, Hayashi T, Suzuki H, Masuko T, Onoda F, Heo SJ, Ikeda H, Shimamoto A, Furuichi Y, Seki M, Enomoto T (Jun 2001). "A novel protein interacts with the Werner's syndrome gene product physically and functionally". J Biol Chem. 276 (23): 20364–9. doi:10.1074/jbc.C100035200. PMID 11301316.
6. "Entrez Gene: WRNIP1 Werner helicase interacting protein 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Tsurimoto T, Shinozaki A, Yano M, et al. (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta". Genes Cells. 10 (1): 13–22. doi:10.1111/j.1365-2443.2004.00812.x. PMID 15670210. S2CID 24977510.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Bish RA, Myers MP (2007). "Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain". J. Biol. Chem. 282 (32): 23184–93. doi:10.1074/jbc.M701042200. PMID 17550899.

External links

• FactorBook WHIP