XPO6

Exportin-6 is a protein that in humans is encoded by the XPO6 gene.[5][6]

XPO6
Identifiers
Aliases	XPO6, EXP6, RANBP20, exportin 6
External IDs	OMIM: 608411 MGI: 2429950 HomoloGene: 12544 GeneCards: XPO6
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.1 Start 28,097,979 bp[1] End 28,211,920 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 126,101,715 bp[2] End 126,200,501 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • Ran GTPase binding • nuclear export signal receptor activity Cellular component • cell membrane • nucleolus • cell nucleus • cytoplasm • cytosol • macromolecular complex Biological process • protein transport • intracellular protein transport • protein export from nucleus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23214	74204
Ensembl	ENSG00000169180	ENSMUSG00000000131
UniProt	Q96QU8	Q924Z6
RefSeq (mRNA)	NM_001270940 NM_015171	NM_028816 NM_001311143
RefSeq (protein)	NP_001257869 NP_055986	NP_001298072 NP_083092
Location (UCSC)	Chr 16: 28.1 – 28.21 Mb	Chr 7: 126.1 – 126.2 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Exportins, such as XPO6, recruit cargo in the nucleoplasm in the presence of Ran-GTP and form ternary export complexes. These complexes are transported through nuclear pore complexes to the cytoplasm, where GTP is hydrolyzed and the export complex is disassembled.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000169180 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000131 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stuven T, Hartmann E, Gorlich D (Oct 2003). "Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes". EMBO J. 22 (21): 5928–40. doi:10.1093/emboj/cdg565. PMC 275422. PMID 14592989.
6. "Entrez Gene: XPO6 exportin 6".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.