YAF2

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.[3][4]

YAF2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2D9G
Identifiers
Aliases	YAF2, YY1 associated factor 2
External IDs	OMIM: 607534 HomoloGene: 136401 GeneCards: YAF2
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q12 Start 42,157,104 bp[1] End 42,238,349 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • metal ion binding • GO:0001105 transcription coactivator activity • GO:0001106 transcription corepressor activity Cellular component • cell nucleus • cytosol • nucleoplasm Biological process • positive regulation of transcription, DNA-templated • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription, DNA-templated • negative regulation of G0 to G1 transition Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10138	n/a
Ensembl	ENSG00000015153	n/a
UniProt	Q8IY57	n/a
RefSeq (mRNA)	NM_001012424 NM_001190977 NM_001190979 NM_001190980 NM_005748 NM_001320080	n/a
RefSeq (protein)	NP_001177906 NP_001177908 NP_001177909 NP_001307009 NP_005739	n/a
Location (UCSC)	Chr 12: 42.16 – 42.24 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.[4]

References

1. GRCh38: Ensembl release 89: ENSG00000015153 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (Mar 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Res. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.
4. "Entrez Gene: YAF2 YY1 associated factor 2".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mädge B, Geisen C, Möröy T, Schwab M (2003). "Yaf2 inhibits Myc biological function". Cancer Lett. 193 (2): 171–6. doi:10.1016/S0304-3835(02)00696-1. PMID 12706874.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ogawa H, Ishiguro K, Gaubatz S, et al. (2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". Science. 296 (5570): 1132–6. doi:10.1126/science.1069861. PMID 12004135. S2CID 34863978.
• Sawa C, Yoshikawa T, Matsuda-Suzuki F, et al. (2002). "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors". J. Biol. Chem. 277 (25): 22484–90. doi:10.1074/jbc.M203060200. PMID 11953439.
• Bannasch D, Mädge B, Schwab M (2001). "Functional interaction of Yaf2 with the central region of MycN". Oncogene. 20 (41): 5913–9. doi:10.1038/sj.onc.1204747. PMID 11593398.

External links

• YAF2 human gene location in the UCSC Genome Browser.
• YAF2 human gene details in the UCSC Genome Browser.