YTHDC2

YTH domain containing 2 is a protein that in humans is encoded by the YTHDC2 gene.[5]

YTHDC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YU6
Identifiers
Aliases	YTHDC2, CAHL, YTH domain containing 2, hYTHDC2
External IDs	OMIM: 616530 MGI: 2448561 HomoloGene: 11265 GeneCards: YTHDC2
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q22.2 Start 113,513,694 bp[1] End 113,595,285 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 44,827,746 bp[2] End 44,889,724 bp[2]
Gene ontology Molecular function • nucleotide binding • GO:0001948 protein binding • RNA polymerase binding • ATP binding • hydrolase activity • GO:0008026 helicase activity • nucleic acid binding • RNA-dependent ATPase activity • RNA binding • N6-methyladenosine-containing RNA binding • GO:0034459 3'-5' RNA helicase activity Cellular component • endoplasmic reticulum • cytoplasm • cell nucleus • ribonucleoprotein granule Biological process • response to tumor necrosis factor • RNA processing • response to interleukin-1 • positive regulation by host of viral genome replication • spermatogenesis • spermatid development • cell differentiation • oogenesis • oocyte development • GO:0007126 meiotic cell cycle • germline cell cycle switching, mitotic to meiotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64848	240255
Ensembl	ENSG00000047188	ENSMUSG00000034653
UniProt	Q9H6S0	B2RR83
RefSeq (mRNA)	NM_022828 NM_001345975 NM_001345976	NM_001163013
RefSeq (protein)	NP_001332904 NP_001332905 NP_073739	NP_001156485
Location (UCSC)	Chr 5: 113.51 – 113.6 Mb	Chr 18: 44.83 – 44.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000047188 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034653 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: YTH domain containing 2".

Further reading

• Bhatnagar P, Purvis S, Barron-Casella E, DeBaun MR, Casella JF, Arking DE, Keefer JR (April 2011). "Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients". Journal of Human Genetics. 56 (4): 316–23. doi:10.1038/jhg.2011.12. PMC 5825003. PMID 21326311.
• Morohashi K, Sahara H, Watashi K, Iwabata K, Sunoki T, Kuramochi K, Takakusagi K, Miyashita H, Sato N, Tanabe A, Shimotohno K, Kobayashi S, Sakaguchi K, Sugawara F (April 2011). Klein R (ed.). "Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B". PLOS ONE. 6 (4): e18285. doi:10.1371/journal.pone.0018285. PMC 3084704. PMID 21559518.
• Gano JJ, Simon JA (February 2010). "A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein". Molecular & Cellular Proteomics. 9 (2): 255–70. doi:10.1074/mcp.M900261-MCP200. PMC 2830838. PMID 19875381.