Yunnan Baiyao

Yunnan Baiyao (or Yunnan Paiyao; simplified Chinese: 云南白药; traditional Chinese: 雲南白藥; pinyin: Yúnnán Báiyào; lit. 'Yunnan White Drug') is a proprietary traditional Chinese medicine marketed and used as an alternative hemostatic product with use in both human and veterinary alternative medicine.[1] The safety and efficacy of Yunnan Baiyao has not been assessed or established by the FDA, European Medicines Agency, or the Australian Therapeutic Goods Administration. There is limited evidence regarding its effectiveness in preventing or treating hemorrhagic and pathological conditions in both humans and animals via oral administration.[2] In a limited number human studies of small sample sizes, administration of Yunnan Baiyao has been shown to correlate with "reduced perioperative bleeding as well as bleeding in various ulcerative–hemorrhagic conditions".[2] A retrospective case-controlled study found Yunnan Baiyao does not delay recurrence of clinical signs or improve survival in dogs with right atrial masses or pericardial effusion.[3] There are multiple routes of drug administration. Yunnan Baiyao is sold in powder, tincture, plaster, paste, aerosol, or tablet form. The medicine, developed by Qu Huangzhang in 1902, is designated as one of two Class-1 protected traditional Chinese medicines which gives it 20 years of trade protection in China.[4] Yunnan Baiyao products are manufactured and distributed by a state-owned enterprise, Yunnan Baiyao Group (SZSE: 000538) in Yunnan, China.

History

Yunnan Baiyao was developed by a Chinese man named Qu Huanzhang from Jiangchuan County in Yunnan Province. He had set out to explore the entire region and taste its hundreds of herbs. In 1902, he formulated "Qu Huanzhang Panacea" which became Yunnan Baiyao ("White medicine from Yunnan")[5] In the Battle of Taierzhuang of 1938 (between Chinese and Japanese forces), Mr. Qu Huanzhang donated more than 30,000 bottles of Yunnan Baiyao to the Chinese National Revolutionary Army, supposedly saving the lives of many soldiers.

As an indication of its value, it is noted that during the 1940s, army commander Wu Xuexian was seriously injured in his right leg. The French hospital in Kunming (capital of Yunnan) recommended amputation to save Wu's life. Wu turned to Qu for help, and to everyone's surprise, recovered without the need for an amputation. Yunnan Baiyao gained the reputation as a miracle remedy. After the death of Qu, his wife, Liao Lanying, donated the secret prescription to the government.[5]

In 1935, pharmacist Qu Huanzhang registered a trademark using his own image. This was Yunnan Baiyao's first attempt at intellectual property (IP) protection. Qu's wife Liao Lanying donated the Yunnan Baiyao recipe in 1956 to the Chinese government. Large-scale production of Yunnan Baiyao began. The Yunnan Baiyao Factory was established in 1971, but the company did not focus on IP protection until the late-1990s, when counterfeit products began affecting the company's business. During this period it registered a series of similar trademarks, including "Yunfeng" and "Yunnan Baiyao." In 2004, the brand was valued at 2.18 billion yuan (US$269 million), ranking 263rd in the World Economic Forum and the World Brand Lab's list of the top 500 Chinese brands.[6]

Patents

In the years prior to 2005, the company spent nearly 1 million yuan (US$123,300) on patent registration, industrialization of patent products and technological innovation. The company applied for three invention patents in 2002. The total number of patents reached 14 in 2004. As of October 2005, the company has applied for 36 invention patents and 40 design patents.[7]

Formula

The formula of, and production processes surrounding Yunnan Baiyao are trade secrets. The company website mentions that the steroid progesterone is in the formula, in addition to several saponins, alkaloids and calcium phosphate.[4] The separate herbal ingredients are reportedly compounded by thirteen separate teams, none of whom have any knowledge of the ingredients the other teams are mixing. The prepared mixed components are then combined by a further team, who have no knowledge of what constitutes them but knows the proportions in which they are combined. Protopanaxadiol and panaxatriol, sapogenins found in ginseng (Panax ginseng) and notoginseng (Panax pseudoginseng), have been detected in Yunnan Baiyao powder formulations through capillary supercritical fluid chromatography.[8] Yunnan Baiyao should not be used with alcohol or when pregnant.[9]

In December 2010, purported lists of ingredients were published on the websites of Amazon.com and the Food and Drug Administration (FDA).[10] The list supposedly containing eight active ingredients of a liquid form of the drug were found in a document published on the FDA website[11] that contains correspondence between the FDA and a distributor of the drug. Ingredient lists were also present in the product information sections for the powdered and capsule forms of the drug on Amazon.com.[12] The proportions and exact manufacturing processes are still unknown.

The 2010 FDA document listed notoginseng (Panax pseudoginseng) root, borneol (Dryobalanops aromatica) crystal, Boea Clarkean (Boea clarkeana) entire plant, Inula Copp (Inula coppa) root, Complanatum (Lycopodium complanatum) rhizome, Chinese Yam (Dioscorea opposita) rhizome, galanga (Alpina offcinarum), cranebill (Erodium stephanianum) aerial parts, camphor (Cinnamonmum camphora) crystal extracts, and peppermint (Menta haplocalyx) leaves as active ingredients in Yunnan Baiyao products.[13]

Under the "Law on Guarding State Secrets", the formula as well as the production processes regarding Yunnan Baiyao are considered secret and possess the longest period of product proprietary secrecy protection of four levels of secrecy under Chinese trade law. As a result, Yunnan Baiyao's exact ingredients are not printed on its packaging in China, and its production process was not disclosed to workers in the factory. Some of the Yunnan Baiyao's products are sold in the US as diet supplements. According to FDA regulations, all diet supplements sold in the US market must list their ingredients on the package and report them to relevant authorities. Officials from the Yunnan Baiyao Group, the exclusive producer of Yunnan Baiyao, denied to Xinhua News Agency Thursday that there is a double standard in Yunnan Baiyao's secret-protection policy, and that ingredients are only reported to drug authorities. "Whoever disclosed the ingredients should be held legally liable," Huang Wushuang, an expert on intellectual property rights at East China University of Political Sciences, said.[7]

Contamination

In early 2013, officials in Sichuan province banned the sale of Baiyao powders and pills over faulty and defective wrappers that led to water contamination in addition to finding products contaminated with mold.[14] In February 2013, the Department of Health of Hong Kong found potentially toxic undeclared aconitum alkaloids in samples of Yunnan Baiyao products, leading to a mandatory recall of products and a temporary ban on the sale of Yunnan Baiyao in the administrative regions of Hong Kong and Macau.[15] In 2019, unauthorised Yunnan Baiyao toothpaste was recalled by Health Canada due to the presence of tranexamic acid, a prescription medication.[16]

Cooperation

The Yunnan Baiyao Group has diversified and expanded into the global pharmaceutical industry. In 2001, the company revealed an adhesive band-aid product in a joint venture with German personal care products maker Beiersdorf AG.[17]

In 2003, 3M initiated contact with Yunnan Baiyao Group Co, Ltd. to discuss potential cooperation opportunities in the area of transdermal pharmaceutical products.[18]

Efficacy

Yunnan Baiyao products are classed as dietary supplements or new drugs by the FDA, and are not generally recognized as safe and effective for the prevention, mitigation, or treatment of wounds, pain, and hemorrhage among other conditions.[19] The European Medicines Agency has not assessed the safety or efficacy of the product as a hemostatic. It is not listed on the Australian Register of Therapeutic Goods (ARTG) for approved sale in Australia, and the quality, safety, or efficacy of Yunnan Baiyao has not been established by the Australian Therapeutic Goods Administration.[20]

Oral administration was shown to produce negligible results in laboratory tests.[2] In vitro studies have suggested a theoretical benefit in the treatment of rheumatoid arthritis.[21] Some studies have found heavy metal levels below oral tolerance levels, however the significance of this finding is not known.[22] Multiple routes of drug administration results in varying degrees of efficacy. Topical administration has been shown to have a degree of efficacy possibly through ultrastructural changes in platelets and platelet-constituent release. The effect of Yunnan Baiyao on the coagulation biochemical system has not been fully elucidated, but it has been suggested that the expression of glycoproteins on platlets plays a role.[23] One in vitro study found that Yunnan Baiyao causes dose and time dependent hemangiosarcoma cell death through initiation of caspase-mediated cell apoptosis in a canine cell cancer line but did not suggest usefulness in patients.[24] Another study found no significant difference from placebo regarding buccal mucosal bleeding time, prothrombin time, activated partial thromboplastin time, and clotting parameters in canines.[25] There is no high-quality evidence supporting the use of Yunnan Baiyao for either rheumatoid arthritis or hemangiosarcoma available in publicly reported scientific literature as of 2019.

Market

Fields

Yunnan Baiyao is focused primarily on diversification of the higher end market segment for pharmaceuticals. Following the success of its adhesive bandages, the Chinese firm added toothpaste to its product line-up. Sales revenue from the Yunnan Baiyao toothpaste grossed 500 million yuan in 2008, making it the fifth most popular toothpaste in China in terms of sales revenue.[26]

Product Research

Over the last five years to 2016, the revenue of the Yunnan Baiyao Group doubled to $3.4 billion in 2016, while net profits increased by 140% to $440 million. Market capitalisation has risen by over 250% since the end of 2011, to more than $13 billion.

Starting around 2005, Yunnan Baiyao expanded further into consumer products including patches and shampoos. Adhesive bandages with Yunnan Baiyao powder are marketed under the slogan "It heals faster with Baiyao"[27]

See also

References
  1. Materia Medica
  2. Frederick, Jami; Boysen, Søren; Wagg, Catherine; Chalhoub, Serge (January 2017). "The effects of oral administration of Yunnan Baiyao on blood coagulation in beagle dogs as measured by kaolin-activated thromboelastography and buccal mucosal bleeding times". Canadian Journal of Veterinary Research. 81 (1): 41–45. ISSN 0830-9000. PMC 5220596. PMID 28154462.
  3. Murphy, Lisa A.; Panek, Cynthia M.; Bianco, Domenico; Nakamura, Reid K. (January 2017). "Use of Yunnan Baiyao and epsilon aminocaproic acid in dogs with right atrial masses and pericardial effusion". Journal of Veterinary Emergency and Critical Care (San Antonio, Tex.: 2001). 27 (1): 121–126. doi:10.1111/vec.12529. ISSN 1476-4431. PMID 27669112.
  4. CBW-Yunnan Baiyao, one of the most famous Chinese Companies in all Chinese Provinces of China, Yunnan Province
  5. Dharmananda, Subhuti. (2007). "Yunnan Baiyao Plaster". Institute for Traditional Medicine. Retrieved March 1, 2018.
  6. "Protecting tradition". www.chinadaily.com.cn. Retrieved 2018-03-19.
  7. "Protecting tradition". www.chinadaily.com.cn.
  8. Li, Y. H.; Li, X. L.; Hong, L.; Liu, J. Y.; Zhang, M. Y. (1991). "[Determination of panaxadiol and panaxatriol in radix notoginseng and Yunnan baiyao by capillary supercritical fluid chromatography]". Yao Xue Xue Bao = Acta Pharmaceutica Sinica. 26 (10): 764–767. ISSN 0513-4870. PMID 1823718.
  9. "Yunnan Paiyao". www.itmonline.org. Retrieved 2018-12-02.
  10. Yunnan Baiyao secret ingredients found on US websites Archived October 12, 2014, at the Wayback Machine
  11. "FDA document containing ingredients" (PDF). FDA. Archived (PDF) from the original on 2011-07-16. Retrieved 2012-02-12.
  12. Product information of Yunnan Baiyao
  13. "Yunnan Baiyao "secret" ingredients found on US websites - GoKunming". 2018-12-02. Archived from the original on 2018-12-02. Retrieved 2018-12-02.
  14. "Yunnan Baiyao pills banned in Sichuan - GoKunming". GoKunming. 2013-01-14. Retrieved 2018-12-02.
  15. "Recall of proprietary Chinese medicines with undeclared aconitum alkaloids (with photos)". www.info.gov.hk. Retrieved 2018-12-02.
  16. Government of Canada, Health Canada (2019-10-04). "Unauthorized". healthycanadians.gc.ca. Retrieved 2020-07-30.
  17. "Yunnan Baiyao diversifies to stay healthy". Chinadaily.com.cn. 2009-05-29. Retrieved 2018-04-28.
  18. Nivea.Paul W Beamish; George Peng (2006)YUNNAN BAIYAO: TRADITIONAL MEDICINE MEETS PRODUCT/MARKET DIVERSIFICATION Published by Ivey Publishing.Retrieved March 15, 2018,
  19. "Modern Herb Shop - 02/26/2015". www.fda.gov. 2019-04-23. Retrieved 2019-05-05.
  20. Administration, Australian Government Department of Health Therapeutic Goods. "Search the TGA website". Therapeutic Goods Administration (TGA). Retrieved 2019-05-05.
  21. He, Hongbing; Ren, Xiaobin; Wang, Xiyue; Shi, Xianzhe; Wang, Xiaolin; Ding, Zhongjuan; Gao, Peng; Xu, Guowang (2012-02-05). "Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts". Journal of Pharmaceutical and Biomedical Analysis. 59: 130–137. doi:10.1016/j.jpba.2011.10.019. ISSN 0731-7085. PMID 22075375.
  22. "Nutrient and metal analyses of Chinese herbal products marketed for veterinary use | Request PDF". ResearchGate. Retrieved 2019-05-05.
  23. Murphy, Lisa A.; Panek, Cynthia M.; Bianco, Domenico; Nakamura, Reid K. (2016-09-26). "Use of Yunnan Baiyao and epsilon aminocaproic acid in dogs with right atrial masses and pericardial effusion". Journal of Veterinary Emergency and Critical Care. 27 (1): 121–126. doi:10.1111/vec.12529. ISSN 1479-3261. PMID 27669112.
  24. Wirth, K. A.; Kow, K.; Salute, M. E.; Bacon, N. J.; Milner, R. J. (September 2016). "In vitro effects of Yunnan Baiyao on canine hemangiosarcoma cell lines". Veterinary and Comparative Oncology. 14 (3): 281–294. doi:10.1111/vco.12100. ISSN 1476-5829. PMID 24976212.
  25. Egger, Christine; Gibbs Ba, Diana; Wheeler, Julie; Voulgaris Ba, Debra (2016-09-01). "The Effect of Yunnan Baiyao on Platelet Activation, Buccal Mucosal Bleeding Time, Prothrombin Time, Activated Partial Thromboplastin Time, and Thromboelastography in Healthy Dogs: A Randomized, Controlled, Blinded Study".
  26. China daily-Yunnan Baiyao diversifies to stay healthy.29th May 2009.http://www.chinadaily.com.cn/business/2009-05/29/content_7952673.htm.
  27. Yunnan Baiyao: The picture of health September 19, 2017 at the forbesindia.www.forbesindia.com/article/cross-border/yunnan-baiyao-the-picture-of-health/48169/1
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