ZBED1

Zinc finger BED domain-containing protein 1 is a protein that in humans is encoded by the ZBED1 gene.[3][4][5]

ZBED1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2CT5
Identifiers
Aliases	ZBED1, ALTE, DREF, TRAMP, hDREF, zinc finger BED-type containing 1
External IDs	OMIM: 300178 HomoloGene: 123965 GeneCards: ZBED1
Gene location (Human) Chr. X chromosome (human)[1] Band X;Y Start 2,486,414 bp[1] End 2,500,976 bp[1]
Gene ontology Molecular function • DNA binding • transposase activity • GO:0001948 protein binding • protein dimerization activity • metal ion binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • identical protein binding • SUMO transferase activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • nuclear chromosome • cell nucleus • nucleoplasm Biological process • regulation of transcription from RNA polymerase II promoter • protein sumoylation • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9189	n/a
Ensembl	ENSG00000214717	n/a
UniProt	O96006	n/a
RefSeq (mRNA)	NM_004729 NM_001171135 NM_001171136	n/a
RefSeq (protein)	NP_001164606 NP_001164607 NP_004720	n/a
Location (UCSC)	Chr X: 2.49 – 2.5 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000214717 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
4. Esposito T, Gianfrancesco F, Ciccodicola A, Montanini L, Mumm S, D'Urso M, Forabosco A (Mar 1999). "A novel pseudoautosomal human gene encodes a putative protein similar to Ac-like transposases". Hum Mol Genet. 8 (1): 61–7. doi:10.1093/hmg/8.1.61. PMID 9887332.
5. "Entrez Gene: ZBED1 zinc finger, BED-type containing 1".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ohshima N, Takahashi M, Hirose F (2003). "Identification of a human homologue of the DREF transcription factor with a potential role in regulation of the histone H1 gene". J. Biol. Chem. 278 (25): 22928–38. doi:10.1074/jbc.M303109200. PMID 12663651.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Yamashita D, Komori H, Higuchi Y, et al. (2007). "Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding". J. Biol. Chem. 282 (10): 7563–75. doi:10.1074/jbc.M607180200. PMID 17209048.
• Yamashita D, Sano Y, Adachi Y, et al. (2007). "hDREF Regulates Cell Proliferation and Expression of Ribosomal Protein Genes". Mol. Cell. Biol. 27 (6): 2003–13. doi:10.1128/MCB.01462-06. PMC 1820502. PMID 17220279.