ZBED3

Zinc finger BED domain-containing protein 3 also known as axin-interacting protein is a protein in humans that is encoded by the ZBED3 gene.[5]

ZBED3
Identifiers
Aliases	ZBED3, zinc finger BED-type containing 3
External IDs	OMIM: 615250 MGI: 1919364 HomoloGene: 12442 GeneCards: ZBED3
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.3 Start 77,072,072 bp[1] End 77,087,285 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D1 Start 95,323,612 bp[2] End 95,337,841 bp[2]
Gene ontology Molecular function • DNA binding • metal ion binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cytoplasm • membrane • cytosol Biological process • positive regulation of canonical Wnt signaling pathway • negative regulation of protein phosphorylation • protein stabilization • Wnt signaling pathway • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84327	72114
Ensembl	ENSG00000132846	ENSMUSG00000041995
UniProt	Q96IU2	Q9D0L1
RefSeq (mRNA)	NM_032367 NM_001329564	NM_028106 NM_001302538 NM_001302539
RefSeq (protein)	NP_001316493 NP_115743	NP_001289467 NP_001289468 NP_082382
Location (UCSC)	Chr 5: 77.07 – 77.09 Mb	Chr 13: 95.32 – 95.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000132846 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041995 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger, BED-type containing 3".

Further reading

• Hayward A, Ghazal A, Andersson G, Andersson L, Jern P (2013). Robinson-Rechavi M (ed.). "ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions". PLOS ONE. 8 (3): e59940. Bibcode:2013PLoSO...859940H. doi:10.1371/journal.pone.0059940. PMC 3606216. PMID 23533661.
• de Miguel-Yanes JM, Shrader P, Pencina MJ, Fox CS, Manning AK, Grant RW, Dupuis J, Florez JC, D'Agostino RB, Cupples LA, Meigs JB (Jan 2011). "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms" (PDF). Diabetes Care. 34 (1): 121–5. doi:10.2337/dc10-1265. PMC 3005447. PMID 20889853.
• Chen T, Li M, Ding Y, Zhang LS, Xi Y, Pan WJ, Tao DL, Wang JY, Li L (Mar 2009). "Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling". The Journal of Biological Chemistry. 284 (11): 6683–9. doi:10.1074/jbc.M807753200. PMC 2652294. PMID 19141611.
• Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, et al. (Jul 2010). "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis". Nature Genetics. 42 (7): 579–89. doi:10.1038/ng.609. PMC 3080658. PMID 20581827.