ZBTB1

Zinc finger and BTB domain containing 1 is a protein in humans that is encoded by the ZBTB1 gene.[5]

ZBTB1
Identifiers
Aliases	ZBTB1, ZNF909, zinc finger and BTB domain containing 1
External IDs	OMIM: 616578 MGI: 2442326 HomoloGene: 8974 GeneCards: ZBTB1
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.3 Start 64,503,712 bp[1] End 64,533,690 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 76,370,266 bp[2] End 76,396,950 bp[2]
Gene ontology Molecular function • DNA binding • protein homodimerization activity • metal ion binding • K63-linked polyubiquitin modification-dependent protein binding • GO:0001948 protein binding • protein heterodimerization activity • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • nuclear body • nucleoplasm • cell nucleus • not the membrane Biological process • positive regulation of T cell differentiation • chromatin remodeling • cell differentiation • positive regulation of pro-T cell differentiation • regulation of transcription, DNA-templated • positive regulation of natural killer cell differentiation • T cell differentiation in thymus • thymus development • immune system process • cellular response to UV • mRNA transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of T cell mediated immunity • translesion synthesis • B cell differentiation • innate immune system • protein homooligomerization • DNA repair • cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22890	268564
Ensembl	ENSG00000126804	ENSMUSG00000033454
UniProt	Q9Y2K1	Q91VL9
RefSeq (mRNA)	NM_001123329 NM_014950	NM_178744 NM_001364323
RefSeq (protein)	NP_001116801 NP_055765	NP_848859 NP_001351252
Location (UCSC)	Chr 14: 64.5 – 64.53 Mb	Chr 12: 76.37 – 76.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

ZBTB1 is essential for the development of lymphocytes in mice: T cells are absent from ZBTB1 mutant mice, and numbers of B cells and natural killer cells are reduced.[6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000126804 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033454 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger and BTB domain containing 1".
6. Siggs OM, Li X, Xia Y, Beutler B (January 2012). "ZBTB1 is a determinant of lymphoid development". The Journal of Experimental Medicine. 209 (1): 19–27. doi:10.1084/jem.20112084. PMC 3260866. PMID 22201126.
7. Punwani D, Simon K, Choi Y, Dutra A, Gonzalez-Espinosa D, Pak E, Naradikian M, Song CH, Zhang J, Bodine DM, Puck JM (August 2012). "Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development". Journal of Immunology. 189 (3): 1253–64. doi:10.4049/jimmunol.1200623. PMC 3401355. PMID 22753936.