ZC3H12A

ZC3H12A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3V32, 3V33, 3V34
Identifiers
Aliases	ZC3H12A, MCPIP, MCPIP1, dJ423B22.1, zinc finger CCCH-type containing 12A, Reg1, MCPIP-1
External IDs	OMIM: 610562 MGI: 2385891 HomoloGene: 11824 GeneCards: ZC3H12A
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	37,484,377 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	125,127,840 bp[2]
Gene ontology
Molecular function	• miRNA binding; • chromatin binding; • metal ion binding; • ribonuclease activity; • GO:0001948 protein binding; • nuclease activity; • endonuclease activity; • mRNA binding; • hydrolase activity; • ribosome binding; • mRNA 3'-UTR binding; • mRNA 3'-UTR AU-rich region binding; • DNA binding; • RNA binding; • endoribonuclease activity; • exoribonuclease activity; • thiol-dependent ubiquitin-specific protease activity; • RNA stem-loop binding;
Cellular component	• cytoplasm; • nucleoplasm; • cytoskeleton; • cell nucleus; • extrinsic component of endoplasmic reticulum membrane; • endoplasmic reticulum; • rough endoplasmic reticulum membrane; • rough endoplasmic reticulum; • P-body; • membrane; • cytoplasmic ribonucleoprotein granule; • macromolecular complex;
Biological process	• positive regulation of p38MAPK cascade; • cellular response to virus; • cell differentiation; • positive regulation of cell death; • positive regulation of autophagy; • negative regulation of interleukin-6 production; • positive regulation of lipid storage; • negative regulation of macrophage activation; • cellular response to tumor necrosis factor; • negative regulation of gene expression; • positive regulation of angiogenesis; • negative regulation of production of miRNAs involved in gene silencing by miRNA; • positive regulation of endothelial cell migration; • multicellular organism development; • protein deubiquitination; • positive regulation of gene expression; • positive regulation of reactive oxygen species metabolic process; • protein oligomerization; • angiogenesis; • regulation of gene expression; • positive regulation of protein import into nucleus; • negative regulation by host of viral genome replication; • negative regulation of tumor necrosis factor production; • positive regulation of miRNA catabolic process; • negative regulation of NF-kappaB transcription factor activity; • positive regulation of defense response to virus by host; • apoptotic process; • RNA phosphodiester bond hydrolysis, endonucleolytic; • immune system process; • negative regulation of muscle cell apoptotic process; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • transcription, DNA-templated; • positive regulation of fat cell differentiation; • positive regulation of transcription from RNA polymerase II promoter; • nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay; • defense response to virus; • cellular response to glucose starvation; • nervous system development; • negative regulation of cytokine production involved in inflammatory response; • cellular response to sodium arsenite; • regulation of transcription, DNA-templated; • negative regulation of protein phosphorylation; • cellular response to ionomycin; • positive regulation of mRNA catabolic process; • cellular response to lipopolysaccharide; • cellular response to oxidative stress; • RNA phosphodiester bond hydrolysis; • negative regulation of nitric oxide biosynthetic process; • cellular response to interleukin-1; • positive regulation of protein deubiquitination; • cellular response to chemokine; • inflammatory response; • 3'-UTR-mediated mRNA destabilization; • negative regulation of cardiac muscle contraction; • positive regulation of execution phase of apoptosis; • RNA phosphodiester bond hydrolysis, exonucleolytic; • cellular response to DNA damage stimulus; • immune response-activating signal transduction; • negative regulation of NIK/NF-kappaB signaling; • T cell receptor signaling pathway; • negative regulation of T-helper 17 cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	80149
	230738
	ENSG00000163874
	ENSMUSG00000042677
	Q5D1E8
	Q5D1E7
	NM_025079; NM_001323550; NM_001323551
	NM_153159
	NP_001310479; NP_001310480; NP_079355
	NP_694799
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger CCCH-type containing 12A is a protein in humans that is encoded by the ZC3H12A gene.[5]

ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.

References

GRCh38: Ensembl release 89: ENSG00000163874 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000042677 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Zinc finger CCCH-type containing 12A".

ZC3H12A

References

Further reading