ZCCHC8

Zinc finger CCHC domain-containing protein 8 is a protein that in humans is encoded by the ZCCHC8 gene.[5][6]

ZCCHC8
Identifiers
Aliases	ZCCHC8, zinc finger CCHC-type containing 8, PFBMFT5
External IDs	OMIM: 616381 MGI: 1917900 HomoloGene: 32349 GeneCards: ZCCHC8
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 122,471,599 bp[1] End 122,501,073 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 123,698,294 bp[2] End 123,721,100 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • zinc ion binding • metal ion binding • nucleic acid binding • RNA binding Cellular component • catalytic step 2 spliceosome • spliceosomal complex • nucleoplasm • nuclear body • cell nucleus • nucleolus • TRAMP complex Biological process • mRNA splicing, via spliceosome • mRNA processing • RNA splicing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55596	70650
Ensembl	ENSG00000033030	ENSMUSG00000029427
UniProt	Q6NZY4	Q9CYA6
RefSeq (mRNA)	NM_017612 NM_001350935 NM_001350936 NM_001350937 NM_001350938	NM_027494
RefSeq (protein)	NP_060082 NP_001337864 NP_001337865 NP_001337866 NP_001337867	NP_081770
Location (UCSC)	Chr 12: 122.47 – 122.5 Mb	Chr 5: 123.7 – 123.72 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000033030 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029427 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
6. "Entrez Gene: ZCCHC8 zinc finger, CCHC domain containing 8".

Further reading

• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gustafson MP, Welcker M, Hwang HC, Clurman BE (2006). "Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins". Biochem. Biophys. Res. Commun. 338 (3): 1359–67. doi:10.1016/j.bbrc.2005.10.090. PMID 16263084.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Matsuoka S, Ballif BA, Smogorzewska A, et al. (2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–6. doi:10.1126/science.1140321. PMID 17525332. S2CID 16648052.