ZDHHC2

Zinc finger, also known as ZDHHC2, is a human gene.[5]

ZDHHC2
Identifiers
Aliases	ZDHHC2, DHHC2, ZNF372, zinc finger DHHC-type containing 2, zinc finger DHHC-type palmitoyltransferase 2
External IDs	MGI: 1923452 HomoloGene: 81667 GeneCards: ZDHHC2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p22 Start 17,156,482 bp[1] End 17,224,799 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A4 Start 40,423,815 bp[2] End 40,510,268 bp[2]
Gene ontology Molecular function • protein-cysteine S-palmitoyltransferase activity • transferase activity • transferase activity, transferring acyl groups • palmitoyltransferase activity Cellular component • integral component of membrane • cell membrane • Golgi apparatus • recycling endosome membrane • integral component of plasma membrane • endoplasmic reticulum • membrane Biological process • cellular protein metabolic process • protein palmitoylation • protein targeting to membrane • peptidyl-L-cysteine S-palmitoylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51201	70546
Ensembl	ENSG00000104219	ENSMUSG00000039470
UniProt	Q9UIJ5	P59267
RefSeq (mRNA)	NM_016353 NM_001362988 NM_001362989	NM_178395 NM_001357249
RefSeq (protein)	NP_057437 NP_001349917 NP_001349918	NP_848482 NP_001344178
Location (UCSC)	Chr 8: 17.16 – 17.22 Mb	Chr 8: 40.42 – 40.51 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000104219 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039470 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: zinc finger".

Further reading

• Zhang J, Planey SL, Ceballos C, et al. (2008). "Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method". Mol. Cell. Proteomics. 7 (7): 1378–88. doi:10.1074/mcp.M800069-MCP200. PMC 2493380. PMID 18296695.
• Li B, Cong F, Tan CP, et al. (2002). "Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity". J. Biol. Chem. 277 (32): 28870–6. doi:10.1074/jbc.M202388200. PMID 12021275.
• Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Oyama T, Miyoshi Y, Koyama K, et al. (2000). "Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis". Genes Chromosomes Cancer. 29 (1): 9–15. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1001>3.0.CO;2-#. PMID 10918388.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ravasi T, Suzuki H, Cannistraci CV, et al. (2010). "An atlas of combinatorial transcriptional regulation in mouse and man". Cell. 140 (5): 744–52. doi:10.1016/j.cell.2010.01.044. PMC 2836267. PMID 20211142.
• Planey SL, Keay SK, Zhang CO, Zacharias DA (2009). "Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling". Mol. Biol. Cell. 20 (5): 1454–63. doi:10.1091/mbc.E08-08-0849. PMC 2649263. PMID 19144824.
• Sharma C, Yang XH, Hemler ME (2008). "DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151". Mol. Biol. Cell. 19 (8): 3415–25. doi:10.1091/mbc.E07-11-1164. PMC 2488315. PMID 18508921.