ZFP91

Zinc finger protein 91 homolog is a protein that in humans is encoded by the ZFP91 gene.[5][6]

ZFP91
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M9A
Identifiers
Aliases	ZFP91, DMS-8, DSM-8, PZF, ZFP-91, ZNF757, FKSG11, ZFP91 zinc finger protein, ZFP91 zinc finger protein, atypical E3 ubiquitin ligase
External IDs	MGI: 104854 HomoloGene: 43144 GeneCards: ZFP91
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 58,579,063 bp[1] End 58,621,550 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 8.73 cM Start 12,767,020 bp[2] End 12,796,126 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • nucleic acid binding • ubiquitin-protein transferase activity • transferase activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • nucleolus Biological process • protein K63-linked ubiquitination • activation of NF-kappaB-inducing kinase activity • protein ubiquitination • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80829	109910
Ensembl	ENSG00000186660	ENSMUSG00000024695
UniProt	Q96JP5	Q62511
RefSeq (mRNA)	NM_053023 NM_001197051	NM_053009
RefSeq (protein)	NP_001183980 NP_444251	NP_443735
Location (UCSC)	Chr 11: 58.58 – 58.62 Mb	Chr 19: 12.77 – 12.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2 type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. In addition to the monocistronic transcript originating from this locus, a co-transcribed variant composed of ZFP91 and CNTF sequence has been identified. The monocistronic and co-transcribed variants encode distinct isoforms. The co-transcription of ZFP91 and CNTF has also been observed in mouse.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000186660 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024695 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Unoki M, Okutsu J, Nakamura Y (May 2003). "Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia". Int J Oncol. 22 (6): 1217–23. doi:10.3892/ijo.22.6.1217. PMID 12738986.
6. "Entrez Gene: ZFP91 zinc finger protein 91 homolog (mouse)".

Further reading

• Iuchi S (2001). "Three classes of C2H2 zinc finger proteins". Cell. Mol. Life Sci. 58 (4): 625–35. doi:10.1007/PL00000885. PMID 11361095. S2CID 6522993.
• Grottke C, Mantwill K, Dietel M, et al. (2000). "Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs". Int. J. Cancer. 88 (4): 535–46. doi:10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V. PMID 11058868.
• Yu Y, Zhang C, Zhou G, et al. (2001). "Gene Expression Profiling in Human Fetal Liver and Identification of Tissue- and Developmental-Stage-Specific Genes through Compiled Expression Profiles and Efficient Cloning of Full-Length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening". Cell Cycle. 5 (6): 641–6. doi:10.4161/cc.5.6.2560. PMID 16582619.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.