ZFYVE1

Zinc finger FYVE domain-containing protein 1 is a protein that in humans is encoded by the ZFYVE1 gene.[5][6][7]

ZFYVE1
Identifiers
Aliases	ZFYVE1, DFCP1, PPP1R172, SR3, TAFF1, ZNFN2A1, zinc finger FYVE-type containing 1
External IDs	OMIM: 605471 MGI: 3026685 HomoloGene: 10945 GeneCards: ZFYVE1
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.2 Start 72,969,451 bp[1] End 73,027,131 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 D1 Start 83,546,558 bp[2] End 83,597,222 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • zinc ion binding • 1-phosphatidylinositol binding • GO:0001948 protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • metal ion binding • phosphatidylinositol-3,4-bisphosphate binding Cellular component • perinuclear region of cytoplasm • autophagosome • ER-mitochondrion membrane contact site • Golgi stack • Golgi apparatus • extrinsic component of omegasome membrane • endoplasmic reticulum • membrane • pre-autophagosomal structure • omegasome Biological process • negative regulation of phosphatase activity • cellular response to starvation • macroautophagy Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	53349	217695
Ensembl	ENSG00000165861	ENSMUSG00000042628
UniProt	Q9HBF4	Q810J8
RefSeq (mRNA)	NM_001281734 NM_001281735 NM_021260 NM_178441	NM_183154 NM_001359166 NM_001359167 NM_001359168
RefSeq (protein)	NP_001268663 NP_001268664 NP_067083 NP_848535	NP_898977 NP_001346095 NP_001346096 NP_001346097
Location (UCSC)	Chr 14: 72.97 – 73.03 Mb	Chr 12: 83.55 – 83.6 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains two zinc-binding FYVE domains in tandem. This protein displays a predominantly Golgi, endoplasmic reticulum and vesicular distribution. Alternatively spliced transcript variants have been found for this gene, and they encode two isoforms with different sizes.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000165861 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042628 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Derubeis AR, Young MF, Jia L, Robey PG, Fisher LW (Nov 2000). "Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library" (PDF). Gene. 255 (2): 195–203. doi:10.1016/S0378-1119(00)00303-6. PMID 11024279.
6. Cheung PC, Trinkle-Mulcahy L, Cohen P, Lucocq JM (Mar 2001). "Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi". Biochem J. 355 (Pt 1): 113–21. doi:10.1042/0264-6021:3550113. PMC 1221718. PMID 11256955.
7. "Entrez Gene: ZFYVE1 zinc finger, FYVE domain containing 1".

Further reading

• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
• Ridley SH, Ktistakis N, Davidson K, et al. (2002). "FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments". J. Cell Sci. 114 (Pt 22): 3991–4000. PMID 11739631.
• Krugmann S, Anderson KE, Ridley SH, et al. (2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol. Cell. 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.