ZFYVE28

Zinc finger FYVE-type containing 28 is a protein that in humans is encoded by the ZFYVE28 gene. [5]

ZFYVE28
Identifiers
Aliases	ZFYVE28, LST2, LYST2, zinc finger FYVE-type containing 28, lst-2
External IDs	OMIM: 614176 MGI: 2684992 HomoloGene: 15119 GeneCards: ZFYVE28
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.3 Start 2,269,582 bp[1] End 2,418,663 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B2 Start 34,194,893 bp[2] End 34,288,449 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • phosphatidylinositol-3-phosphate binding • metal ion binding Cellular component • cytoplasm • cytosol • endosome • early endosome membrane • membrane Biological process • negative regulation of epidermal growth factor-activated receptor activity • negative regulation of epidermal growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57732	231125
Ensembl	ENSG00000159733	ENSMUSG00000037224
UniProt	Q9HCC9	Q6ZPK7
RefSeq (mRNA)	NM_001172656 NM_001172657 NM_001172658 NM_001172659 NM_001172660 NM_020972	NM_001015039
RefSeq (protein)	NP_001166127 NP_001166128 NP_001166129 NP_001166130 NP_001166131 NP_066023	NP_001015039
Location (UCSC)	Chr 4: 2.27 – 2.42 Mb	Chr 5: 34.19 – 34.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000159733 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037224 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger FYVE-type containing 28". Retrieved 2016-12-27.

Further reading

• Mosesson Y, Chetrit D, Schley L, Berghoff J, Ziv T, Carvalho S, Milanezi F, Admon A, Schmitt F, Ehrlich M, Yarden Y (2009). "Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling". Dev. Cell. 16 (5): 687–98. doi:10.1016/j.devcel.2009.03.015. PMC 3356849. PMID 19460345.