ZHX2

Zinc fingers and homeoboxes protein 2 is a protein that in humans is encoded by the ZHX2 gene.[5][6][7]

ZHX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DMP, 3NAU
Identifiers
Aliases	ZHX2, AFR1, RAF, zinc fingers and homeoboxes 2
External IDs	OMIM: 609185 MGI: 2683087 HomoloGene: 8968 GeneCards: ZHX2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.13 Start 122,781,655 bp[1] End 122,974,510 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 D1|15 24.01 cM Start 57,694,665 bp[2] End 57,839,832 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001948 protein binding • protein homodimerization activity • GO:0001106 transcription corepressor activity • metal ion binding • identical protein binding • protein heterodimerization activity • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • nucleoplasm • cytosol • cell membrane Biological process • regulation of transcription from RNA polymerase II promoter • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • mRNA catabolic process • negative regulation of neuron differentiation • somatic stem cell population maintenance • transcription, DNA-templated • retinal bipolar neuron differentiation • nervous system development • cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22882	387609
Ensembl	ENSG00000178764	ENSMUSG00000071757
UniProt	Q9Y6X8	Q8C0C0
RefSeq (mRNA)	NM_014943 NM_001362797	NM_199449
RefSeq (protein)	NP_055758 NP_001349726	NP_955520
Location (UCSC)	Chr 8: 122.78 – 122.97 Mb	Chr 15: 57.69 – 57.84 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.[7]

See also

• Chromosome 8 (human)
• NFYA
• Protein dimer

References

1. GRCh38: Ensembl release 89: ENSG00000178764 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071757 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
6. Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K (Jul 2003). "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor". Biochem J. 373 (Pt 3): 747–57. doi:10.1042/BJ20030171. PMC 1223552. PMID 12741956.
7. "Entrez Gene: ZHX2 zinc fingers and homeoboxes 2".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kawata H, Yamada K, Shou Z, et al. (2004). "The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3". Gene. 323: 133–40. doi:10.1016/j.gene.2003.09.013. PMID 14659886.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• de Andrade TG, Peterson KR, Cunha AF, et al. (2006). "Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster". Blood Cells Mol. Dis. 37 (2): 82–90. doi:10.1016/j.bcmd.2006.07.003. PMID 16952470.
• Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome". J. Biol. Chem. 281 (51): 39681–92. doi:10.1074/jbc.M606664200. PMID 17056598.
• Hu S, Zhang M, Lv Z, et al. (2007). "Expression of zinc-fingers and homeoboxes 2 in hepatocellular carcinogenesis: a tissue microarray and clinicopathological analysis". Neoplasma. 54 (3): 207–11. PMID 17447851.