ZIC1

ZIC1 is a member of the Zinc finger of the cerebellum (ZIC) protein family.[5][6]

ZIC1
Identifiers
Aliases	ZIC1, ZIC, ZNF201, CRS6, Zic family member 1, BAIDCS
External IDs	OMIM: 600470 MGI: 106683 HomoloGene: 2562 GeneCards: ZIC1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q24 Start 147,393,422 bp[1] End 147,510,293 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E3.2|9 48.26 cM Start 91,358,058 bp[2] End 91,365,810 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • nucleic acid binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cytoplasm • cell nucleus Biological process • pattern specification process • cell differentiation • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • transcription, DNA-templated • nervous system development • positive regulation of transcription, DNA-templated • multicellular organism development • regulation of smoothened signaling pathway • central nervous system development • brain development • inner ear morphogenesis • spinal cord development • positive regulation of protein import into nucleus • positive regulation of transcription from RNA polymerase II promoter • adult walking behavior Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7545	22771
Ensembl	ENSG00000152977	ENSMUSG00000032368
UniProt	Q15915	P46684
RefSeq (mRNA)	NM_003412	NM_009573 NM_001376941
RefSeq (protein)	NP_003403	NP_033599 NP_001363870
Location (UCSC)	Chr 3: 147.39 – 147.51 Mb	Chr 9: 91.36 – 91.37 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

ZIC1 is classified as a ZIC protein due to conservation of the five C2H2 zinc fingers, which enables the protein to interact with DNA and proteins. ZIC1 is found in close genomic configuration in another member of this protein family, ZIC4. Correct function of these proteins in critical for early development, and as such mutations of the genes encoding these proteins is known to result in various congenital defects. For example, if function of both ZIC1 and ZIC4 is lost (which can occur via an interstitial deletion due to their adjacent location) then this may result in the Dandy-Walker malformation.[7]

Interactions

ZIC1 has been shown to interact with GLI1[8] and GLI3.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000152977 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032368 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ali RG, Bellchambers HM, Arkell RM (November 2012). "Zinc finger of the cerebellum (Zic): Transcription factors and co-factors". Int J Biochem Cell Biol. 44 (11): 2065–8. doi:10.1016/j.biocel.2012.08.012. PMID 22964024.
6. "Entrez Gene: ZIC1 Zic family member 1 (odd-paired homolog, Drosophila)".
7. Grinberg I, Northrup H, Ardinger H, Prasad C, Dobyns WB, Millen KJ (October 2004). "Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation". Nat Genet. 36 (10): 1053–5. doi:10.1038/ng1420. PMID 15338008.
8. Koyabu, Y; Nakata K; Mizugishi K; Aruga J; Mikoshiba K (March 2001). "Physical and functional interactions between Zic and Gli proteins". J. Biol. Chem. United States. 276 (10): 6889–92. doi:10.1074/jbc.C000773200. ISSN 0021-9258. PMID 11238441.

Further reading

• Houtmeyers R, Souopgui J, Tejpar S, Arkell R (2013). "The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis". Cell Mol Life Sci. 70 (20): 3791–811. doi:10.1007/s00018-013-1285-5. PMID 23443491. S2CID 8660667.
• Bagutti C, Forro G, Ferralli J, et al. (2004). "The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription". J. Cell Sci. 116 (Pt 14): 2957–66. doi:10.1242/jcs.00603. PMID 12783990.
• Pourebrahim R, Van Dam K, Bauters M, et al. (2007). "ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations". FEBS Lett. 581 (26): 5122–6. doi:10.1016/j.febslet.2007.09.061. PMID 17936758. S2CID 25349004.