ZMYND11

Zinc finger MYND domain-containing protein 11 is a protein that in humans is encoded by the ZMYND11 gene.[5][6][7]

ZMYND11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NS5, 5HDA
Identifiers
Aliases	ZMYND11, BRAM1, BS69, MRD30, zinc finger MYND-type containing 11
External IDs	OMIM: 608668 MGI: 1913755 HomoloGene: 4828 GeneCards: ZMYND11
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p15.3 Start 134,465 bp[1] End 254,637 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A1 Start 9,684,833 bp[2] End 9,765,330 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • chromatin binding • GO:0001104 transcription coregulator activity • metal ion binding • GO:0001948 protein binding • GO:0001106 transcription corepressor activity • histone binding • double-stranded DNA binding • zinc ion binding • methylated histone binding Cellular component • nucleoplasm • chromosome • cell nucleus Biological process • regulation of transcription, DNA-templated • negative regulation of extrinsic apoptotic signaling pathway • negative regulation of I-kappaB kinase/NF-kappaB signaling • transcription, DNA-templated • negative regulation of JNK cascade • cell cycle • cellular proliferation • GO:0022415 viral process • regulation of transcription elongation from RNA polymerase II promoter • defense response to virus • negative regulation of nucleic acid-templated transcription • chromatin organization • negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10771	66505
Ensembl	ENSG00000015171	ENSMUSG00000021156
UniProt	Q15326	Q8R5C8
RefSeq (mRNA)	NM_001202464 NM_001202465 NM_001202466 NM_001202467 NM_001202468 NM_006624 NM_212479 NM_001330057	NM_001199141 NM_144516 NM_001347470 NM_001347471 NM_001347472 NM_001347473 NM_001347474 NM_001347476 NM_001347477 NM_001347479 NM_001347480 NM_001347481
RefSeq (protein)	NP_001189393 NP_001189394 NP_001189395 NP_001189396 NP_001189397 NP_001316986 NP_006615 NP_997644 NP_001357026 NP_001357027 NP_001357028 NP_001357029 NP_001357030 NP_001357031 NP_001357032 NP_001357033 NP_001357034 NP_001357035 NP_001357036 NP_001357037 NP_001357038 NP_001357039 NP_001357040 NP_001357041 NP_001357042 NP_001357043 NP_001357044 NP_001357045 NP_001357046 NP_001357047 NP_001357048 NP_001357049 NP_001357050 NP_001357051 NP_001357052 NP_001357053	NP_001186070 NP_001334399 NP_001334400 NP_001334401 NP_001334402 NP_001334403 NP_001334405 NP_001334406 NP_001334408 NP_001334409 NP_001334410 NP_653099
Location (UCSC)	Chr 10: 0.13 – 0.25 Mb	Chr 13: 9.68 – 9.77 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

Interactions

ZMYND11 has been shown to interact with:

• BMPR1A,[8]
• C11orf30,[9]
• ETS2,[10] and
• TAB1.[8]
• H3.3K36me3 [11]

References

1. GRCh38: Ensembl release 89: ENSG00000015171 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021156 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hateboer G, Gennissen A, Ramos YF, Kerkhoven RM, Sonntag-Buck V, Stunnenberg HG, Bernards R (Jul 1995). "BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation". The EMBO Journal. 14 (13): 3159–69. doi:10.1002/j.1460-2075.1995.tb07318.x. PMC 394377. PMID 7621829.
6. Masselink H, Bernards R (Mar 2000). "The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR". Oncogene. 19 (12): 1538–46. doi:10.1038/sj.onc.1203421. PMID 10734313.
7. "Entrez Gene: ZMYND11 zinc finger, MYND domain containing 11".
8. Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (Apr 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes to Cells. 3 (4): 257–64. doi:10.1046/j.1365-2443.1998.00186.x. PMID 9663660. S2CID 29818690.
9. Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T (Nov 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell. 115 (5): 523–35. doi:10.1016/s0092-8674(03)00930-9. PMID 14651845. S2CID 18911371.
10. Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Research. 23 (3A): 2173–8. PMID 12894593.
11. Wen, Hong; Li, Yuanyuan; Xi, Yuanxin; Jiang, Shiming; Stratton, Sabrina; Peng, Danni; Tanaka, Kaori; Ren, Yongfeng; Xia, Zheng; Wu, Jun; Li, Bing; Barton, Michelle C.; Li, Wei; Li, Haitao; Shi, Xiaobing (2014). "ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression". Nature. 508 (7495): 263–268. doi:10.1038/nature13045. PMC 4142212. PMID 24590075.

Further reading

• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (Apr 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes to Cells. 3 (4): 257–64. doi:10.1046/j.1365-2443.1998.00186.x. PMID 9663660. S2CID 29818690.
• Lo KW, Naisbitt S, Fan JS, Sheng M, Zhang M (Apr 2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". The Journal of Biological Chemistry. 276 (17): 14059–66. doi:10.1074/jbc.M010320200. PMID 11148209.
• Ansieau S, Leutz A (Feb 2002). "The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif". The Journal of Biological Chemistry. 277 (7): 4906–10. doi:10.1074/jbc.M110078200. PMID 11733528.
• Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Research. 23 (3A): 2173–8. PMID 12894593.
• Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T (Nov 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell. 115 (5): 523–35. doi:10.1016/S0092-8674(03)00930-9. PMID 14651845. S2CID 18911371.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Isobe T, Uchida C, Hattori T, Kitagawa K, Oda T, Kitagawa M (Jan 2006). "Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69". Biochemical and Biophysical Research Communications. 339 (1): 367–74. doi:10.1016/j.bbrc.2005.11.028. hdl:10271/294. PMID 16300738.
• Wan J, Zhang W, Wu L, Bai T, Zhang M, Lo KW, Chui YL, Cui Y, Tao Q, Yamamoto M, Akira S, Wu Z (Jan 2006). "BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway". Molecular and Cellular Biology. 26 (2): 448–56. doi:10.1128/MCB.26.2.448-456.2006. PMC 1346911. PMID 16382137.
• Velasco G, Grkovic S, Ansieau S (Jun 2006). "New insights into BS69 functions". The Journal of Biological Chemistry. 281 (24): 16546–50. doi:10.1074/jbc.M600573200. PMID 16565076.