ZNF16

Zinc finger protein 16 is a protein that in humans is encoded by the ZNF16 gene.[3]

ZNF16
Identifiers
Aliases	ZNF16, HZF1, KOX9, zinc finger protein 16
External IDs	OMIM: 601262 HomoloGene: 56008 GeneCards: ZNF16
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 144,930,358 bp[1] End 144,950,888 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001948 protein binding • metal ion binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • nucleolus Biological process • positive regulation of cell cycle phase transition • positive regulation of kinase activity • cell cycle • negative regulation of apoptotic process • regulation of transcription, DNA-templated • positive regulation of megakaryocyte differentiation • positive regulation of cell division • positive regulation of erythrocyte differentiation • transcription, DNA-templated • positive regulation of cell proliferation • cellular response to sodium dodecyl sulfate • cell division • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7564	n/a
Ensembl	ENSG00000170631	n/a
UniProt	P17020	n/a
RefSeq (mRNA)	NM_001029976 NM_006958	n/a
RefSeq (protein)	NP_001025147 NP_008889	n/a
Location (UCSC)	Chr 8: 144.93 – 144.95 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

The protein encoded by this gene contains a C2H2 type of zinc finger, and thus may function as a transcription factor. This gene is located in a region close to ZNF7/KOX4, a gene also encoding a zinc finger protein, on chromosome 8. Two alternatively spliced variants, encoding the same protein, have been identified.[3]

References

1. GRCh38: Ensembl release 89: ENSG00000170631 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: ZNF16 zinc finger protein 16".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dreier B, Segal DJ, Barbas CF (2000). "Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains". J. Mol. Biol. 303 (4): 489–502. doi:10.1006/jmbi.2000.4133. PMID 11054286.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Rousseau-Merck MF, Duro D, Berger R, Thiesen HJ (1995). "Chromosomal localization of two KOX zinc finger genes on chromosome bands 7q21-q22". Ann. Genet. 38 (2): 81–4. PMID 7486829.
• Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–74. PMID 2288909.