ZNF331

Zinc finger protein 331 is a protein that in humans is encoded by the ZNF331 gene.[3]

ZNF331
Identifiers
Aliases	ZNF331, RITA, ZNF361, ZNF463, zinc finger protein 331
External IDs	OMIM: 606043 HomoloGene: 41276 GeneCards: ZNF331
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 53,519,527 bp[1] End 53,580,269 bp[1]
Gene ontology Molecular function • DNA binding • zinc ion binding • metal ion binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • intracellular • cell nucleus Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55422	n/a
Ensembl	ENSG00000130844	n/a
UniProt	Q9NQX6 Q71QC5	n/a
RefSeq (mRNA)	NM_001079906 NM_001079907 NM_001253798 NM_001253799 NM_001253800 NM_001253801 NM_018555 NM_001317113 NM_001317114 NM_001317115 NM_001317116 NM_001317117 NM_001317118 NM_001317119 NM_001317120 NM_001317121	n/a
RefSeq (protein)	NP_001073375 NP_001073376 NP_001240727 NP_001240728 NP_001240729 NP_001240730 NP_001304042 NP_001304043 NP_001304044 NP_001304045 NP_001304046 NP_001304047 NP_001304048 NP_001304049 NP_001304050 NP_061025 NP_001073375.1 NP_001304050.1	n/a
Location (UCSC)	Chr 19: 53.52 – 53.58 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form one family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM][3]

References

1. GRCh38: Ensembl release 89: ENSG00000130844 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: ZNF331 zinc finger protein 331".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Meiboom M, Murua Escobar H, Winkler S, et al. (2004). "Molecular characterization and mapping of the canine KRAB zinc finger gene ZNF331". Anim. Genet. 35 (3): 262–3. doi:10.1111/j.1365-2052.2004.01146.x. PMID 15147412.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Meiboom M, Murua Escobar H, Pentimalli F, et al. (2003). "A 3.4-kbp transcript of ZNF331 is solely expressed in follicular thyroid adenomas". Cytogenet. Genome Res. 101 (2): 113–7. doi:10.1159/000074165. PMID 14610350. S2CID 22276378.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wu H, Zhang S, Qiu W, et al. (2001). "Isolation, characterization, and mapping of a novel human KRAB zinc finger protein encoding gene ZNF463". Biochim. Biophys. Acta. 1518 (1–2): 190–3. doi:10.1016/s0167-4781(01)00172-5. PMID 11267678.
• Rippe V, Belge G, Meiboom M, et al. (2000). "A KRAB zinc finger protein gene is the potential target of 19q13 translocation in benign thyroid tumors". Genes Chromosomes Cancer. 26 (3): 229–36. doi:10.1002/(SICI)1098-2264(199911)26:3<229::AID-GCC7>3.0.CO;2-J. PMID 10502321.