ZRF1

DnaJ homolog subfamily C member 2 is a protein that in humans is encoded by the DNAJC2 gene.[5][6]

DNAJC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M2E
Identifiers
Aliases	DNAJC2, MPHOSPH11, MPP11, ZRF1, ZUO1, DnaJ heat shock protein family (Hsp40) member C2
External IDs	OMIM: 605502 MGI: 99470 HomoloGene: 31656 GeneCards: DNAJC2
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 103,312,289 bp[1] End 103,344,830 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A3|5 9.97 cM Start 21,757,267 bp[2] End 21,785,251 bp[2]
Gene ontology Molecular function • DNA binding • Hsp70 protein binding • histone binding • chromatin binding • ATPase activator activity • RNA binding • ubiquitin modification-dependent histone binding • GO:0001948 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cytoplasm • cytosol • not the membrane • cell nucleus • nucleoplasm Biological process • positive regulation of transcription, DNA-templated • regulation of cellular response to heat • DNA replication • 'de novo' cotranslational protein folding • regulation of transcription, DNA-templated • negative regulation of DNA biosynthetic process • transcription, DNA-templated • positive regulation of ATPase activity • covalent chromatin modification • chromatin organization • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27000	22791
Ensembl	ENSG00000105821	ENSMUSG00000029014
UniProt	Q99543	P54103
RefSeq (mRNA)	NM_001129887 NM_014377 NM_001362667 NM_001362668	NM_009584
RefSeq (protein)	NP_001123359 NP_055192 NP_001349596 NP_001349597	NP_033610
Location (UCSC)	Chr 7: 103.31 – 103.34 Mb	Chr 5: 21.76 – 21.79 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000105821 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029014 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239.
6. "Entrez Gene: ZRF1 zuotin related factor 1".

Further reading

• Resto VA, Caballero OL, Buta MR, et al. (2000). "A putative oncogenic role for MPP11 in head and neck squamous cell cancer". Cancer Res. 60 (19): 5529–35. PMID 11034098.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Greiner J, Ringhoffer M, Taniguchi M, et al. (2003). "Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia". Int. J. Cancer. 106 (2): 224–31. doi:10.1002/ijc.11200. PMID 12800198. S2CID 24284888.
• Greiner J, Ringhoffer M, Taniguchi M, et al. (2004). "mRNA expression of leukemia-associated antigens in patients with acute myeloid leukemia for the development of specific immunotherapies". Int. J. Cancer. 108 (5): 704–11. doi:10.1002/ijc.11623. PMID 14696097. S2CID 24565397.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hundley HA, Walter W, Bairstow S, Craig EA (2005). "Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous". Science. 308 (5724): 1032–4. doi:10.1126/science.1109247. PMID 15802566. S2CID 24164629.
• Otto H, Conz C, Maier P, et al. (2005). "The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex". Proc. Natl. Acad. Sci. U.S.A. 102 (29): 10064–9. doi:10.1073/pnas.0504400102. PMC 1177401. PMID 16002468.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.