ZZZ3

ZZ-type zinc finger-containing protein 3 is a protein that in humans is encoded by the ZZZ3 gene.[5]

ZZZ3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FC7, 2YUM
Identifiers
Aliases	ZZZ3, ATAC1, zinc finger ZZ-type containing 3
External IDs	MGI: 1920453 HomoloGene: 9182 GeneCards: ZZZ3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.1 Start 77,562,416 bp[1] End 77,683,419 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H3 Start 152,395,473 bp[2] End 152,462,826 bp[2]
Gene ontology Molecular function • DNA binding • zinc ion binding • GO:0001948 protein binding • metal ion binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • Ada2/Gcn5/Ada3 transcription activator complex • nucleolus • cell nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26009	108946
Ensembl	ENSG00000036549	ENSMUSG00000039068
UniProt	Q8IYH5	Q6KAQ7
RefSeq (mRNA)	NM_001308237 NM_015534	NM_001080755 NM_001287139 NM_198416 NM_001346655 NM_001355673
RefSeq (protein)	NP_001295166 NP_056349 NP_001363075 NP_001363076 NP_001363077 NP_001363078 NP_001363080 NP_001363082 NP_001363083 NP_001363084 NP_001363085	NP_001074224 NP_001274068 NP_001333584 NP_001342602
Location (UCSC)	Chr 1: 77.56 – 77.68 Mb	Chr 3: 152.4 – 152.46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Model organisms

Zzz3 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Abnormal
Recessive lethal study	Abnormal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Tail epidermis wholemount	Normal
Skin Histopathology	Normal
Brain histopathology	Normal
Citrobacter infection	Normal[6]
All tests and analysis from[7][8]

Model organisms have been used in the study of ZZZ3 function. A conditional knockout mouse line, called Zzz3^{tm1a(EUCOMM)Wtsi}[9][10] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[11][12][13]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[7][14] Twenty four tests were carried out on mutant mice and two significant abnormalities were observed.[7] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice and no further abnormal phenotypes were identified.[7]

See also

• ZZ zinc finger

References

1. GRCh38: Ensembl release 89: ENSG00000036549 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039068 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: zinc finger, ZZ-type containing 3". Retrieved 2011-08-30.
6. "Citrobacter infection data for Zzz3". Wellcome Trust Sanger Institute.
7. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
8. Mouse Resources Portal, Wellcome Trust Sanger Institute.
9. "International Knockout Mouse Consortium".
10. "Mouse Genome Informatics".
11. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
12. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
13. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
14. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

• Guelman S, Suganuma T, Florens L, Swanson SK, Kiesecker CL, Kusch T, Anderson S, Yates JR, Washburn MP, Abmayr SM, Workman JL (Feb 2006). "Host cell factor and an uncharacterized SANT domain protein are stable components of ATAC, a novel dAda2A/dGcn5-containing histone acetyltransferase complex in Drosophila". Molecular and Cellular Biology. 26 (3): 871–82. doi:10.1128/MCB.26.3.871-882.2006. PMC 1347012. PMID 16428443.
• Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y (Mar 2010). "An atlas of combinatorial transcriptional regulation in mouse and man". Cell. 140 (5): 744–52. doi:10.1016/j.cell.2010.01.044. PMC 2836267. PMID 20211142.