Zinc finger protein 334

Zinc finger protein 334 is a protein that in humans is encoded by the ZNF334 gene. [4]

ZNF334
Identifiers
Aliases	ZNF334, zinc finger protein 334
External IDs	MGI: 2388656 HomoloGene: 23076 GeneCards: ZNF334
Gene location (Mouse) Chr. Chromosome 2 (mouse)[1] Band 2|2 H3 Start 165,374,264 bp[1] End 165,388,259 bp[1]
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • metal ion binding • nucleic acid binding • GO:0001948 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • intracellular • cell nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55713	228876
Ensembl	ENSG00000198185	ENSMUSG00000017667
UniProt	Q9HCZ1	A2A4U6
RefSeq (mRNA)	NM_001270497 NM_018102 NM_199441	NM_178411
RefSeq (protein)	NP_001257426 NP_060572 NP_001340742 NP_001340743 NP_001340744 NP_001340745 NP_001340746 NP_001340747 NP_001340748 NP_001340749 NP_001340750 NP_001340751 NP_001340752 NP_001340753 NP_001340754 NP_001340755 NP_955473	NP_848498
Location (UCSC)	n/a	Chr 2: 165.37 – 165.39 Mb
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

References

1. GRCm38: Ensembl release 89: ENSMUSG00000017667 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: Zinc finger protein 334". Retrieved 2016-03-10.

Further reading

• Henc I, Soroczyńska-Cybula M, Bryl E, Witkowski JM (2015). "The in vitro modulatory effect of TNFα on the mRNA expression and protein levels of zinc finger protein ZNF334 in CD4(+) lymphocytes of healthy people". Acta Biochim. Pol. 62 (1): 113–7. doi:10.18388/abp.2014_857. PMID 25738173.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.