Zinc finger protein 592

Zinc finger protein 592 is a protein that in humans is encoded by the ZNF592 gene. [5]

ZNF592
Identifiers
Aliases	ZNF592, CAMOS, SCAR5, zinc finger protein 592
External IDs	OMIM: 613624 MGI: 2443541 HomoloGene: 8759 GeneCards: ZNF592
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q25.3 Start 84,748,592 bp[1] End 84,806,445 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 D3 Start 80,993,681 bp[2] End 81,045,164 bp[2]
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • metal ion binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9640	233410
Ensembl	ENSG00000166716	ENSMUSG00000005621
UniProt	Q92610	Q8BHZ4
RefSeq (mRNA)	NM_014630	NM_178707
RefSeq (protein)	NP_055445	NP_848822
Location (UCSC)	Chr 15: 84.75 – 84.81 Mb	Chr 7: 80.99 – 81.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is thought to play a role in a complex developmental pathway and the regulation of genes involved in cerebellar development. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia.

References

1. GRCh38: Ensembl release 89: ENSG00000166716 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005621 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger protein 592". Retrieved 2016-03-07.

Further reading

• Huang J, Zheng DL, Qin FS, Cheng N, Chen H, Wan BB, Wang YP, Xiao HS, Han ZG (2010). "Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling". J. Clin. Invest. 120 (1): 223–41. doi:10.1172/JCI38012. PMC 2798676. PMID 20038795.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.