3'-nucleotidase
In enzymology, a 3'-nucleotidase (EC 3.1.3.6) is an enzyme that catalyzes the chemical reaction
- a 3'-ribonucleotide + H2O a ribonucleoside + phosphate
| 3'-nucleotidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.3.6 | ||||||||
| CAS number | 9025-84-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 3'-ribonucleotide and H2O, whereas its two products are ribonucleoside and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 3'-ribonucleotide phosphohydrolase. Other names in common use include 3'-mononucleotidase, 3'-phosphatase, and 3'-ribonucleotidase. This enzyme participates in purine metabolism and pyrimidine metabolism.
References
- SHUSTER L, KAPLAN NO (1953). "A specific b nucleotidase". J. Biol. Chem. 201 (2): 535–46. PMID 13061389.
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