ADCY9

Adenylyl cyclase type 9 is an enzyme that in humans is encoded by the ADCY9 gene.[5][6]

ADCY9
Identifiers
Aliases	ADCY9, AC9, ACIX, adenylate cyclase 9
External IDs	OMIM: 603302 MGI: 108450 HomoloGene: 868 GeneCards: ADCY9
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 3,953,387 bp[1] End 4,116,442 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A1|16 2.42 cM Start 4,287,529 bp[2] End 4,420,498 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • metal ion binding • lyase activity • phosphorus-oxygen lyase activity • ATP binding • adenylate cyclase activity • guanylate cyclase activity Cellular component • membrane • integral component of plasma membrane • axon • dendrite • cell membrane • integral component of membrane • guanylate cyclase complex, soluble • intracellular Biological process • GO:0007243 intracellular signal transduction • cellular response to glucagon stimulus • cyclic nucleotide biosynthetic process • adenylate cyclase-activating adrenergic receptor signaling pathway • renal water homeostasis • signal transduction • cAMP biosynthetic process • adenylate cyclase-activating G-protein coupled receptor signaling pathway • cGMP biosynthetic process • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway • activation of adenylate cyclase activity • activation of protein kinase A activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	115	11515
Ensembl	ENSG00000162104	ENSMUSG00000005580
UniProt	O60503	P51830
RefSeq (mRNA)	NM_001116	NM_001291910 NM_009624
RefSeq (protein)	NP_001107	NP_001278839 NP_033754
Location (UCSC)	Chr 16: 3.95 – 4.12 Mb	Chr 16: 4.29 – 4.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000162104 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005580 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hacker BM, Tomlinson JE, Wayman GA, Sultana R, Chan G, Villacres E, Disteche C, Storm DR (Apr 1999). "Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9)". Genomics. 50 (1): 97–104. doi:10.1006/geno.1998.5293. PMID 9628827.
6. "Entrez Gene: ADCY9 adenylate cyclase 9".

External links

• Human ADCY9 genome location and ADCY9 gene details page in the UCSC Genome Browser.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Paterson JM, Smith SM, Harmar AJ, Antoni FA (1995). "Control of a novel adenylyl cyclase by calcineurin". Biochem. Biophys. Res. Commun. 214 (3): 1000–8. doi:10.1006/bbrc.1995.2385. PMID 7575502.
• Premont RT, Matsuoka I, Mattei MG, et al. (1996). "Identification and characterization of a widely expressed form of adenylyl cyclase". J. Biol. Chem. 271 (23): 13900–7. doi:10.1074/jbc.271.23.13900. PMID 8662814.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Arch. 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566. S2CID 7620262.
• Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–36. doi:10.1097/00002030-200004140-00001. PMID 10807185. S2CID 22105709.
• Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". J. Allergy Clin. Immunol. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
• Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302. S2CID 24053412.
• Toyota T, Hattori E, Meerabux J, et al. (2002). "Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders". Am. J. Med. Genet. 114 (1): 84–92. doi:10.1002/ajmg.10117. PMID 11840511.
• Speth C, Schabetsberger T, Mohsenipour I, et al. (2002). "Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons". J. Virol. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542.
• Toyota T, Yamada K, Saito K, et al. (2002). "Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder". Mol. Psychiatry. 7 (5): 450–2. doi:10.1038/sj.mp.4000992. PMID 12082561.
• Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID 12503609. S2CID 36697419.
• Small KM, Brown KM, Theiss CT, et al. (2004). "An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation". Pharmacogenetics. 13 (9): 535–41. doi:10.1097/00008571-200309000-00002. PMID 12972952.
• Cumbay MG, Watts VJ (2004). "Novel regulatory properties of human type 9 adenylate cyclase". J. Pharmacol. Exp. Ther. 310 (1): 108–15. doi:10.1124/jpet.104.065748. PMID 14996950. S2CID 6161734.
• Tantisira KG, Small KM, Litonjua AA, et al. (2005). "Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways". Hum. Mol. Genet. 14 (12): 1671–7. doi:10.1093/hmg/ddi175. PMID 15879435.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.