Abraham Zangen

Abraham Zangen (Hebrew: אברהם צנגן‎, born 1969)[1] is an Israeli professor of neuroscience, head of the brain stimulation and behavior lab and chair of the psychobiology brain program at Ben-Gurion University of the Negev (BGU).[2]

Abraham Zangen
Born1969
Jerusalem, Israel
Scientific career
InstitutionsWeizmann Institute of Science; Ben Gurion University of the Negev

Biography

Abraham Zangen was born in Jerusalem.[3] He earned his B.Sc in pharmacology from the Hebrew University and his PhD from the Bar Ilan University in Israel in 1999.[2] He then did a postdoc at the U.S. National Institutes of Health (NIH), which ended in 2003.[1]

Scientific career

Zangen studies neuroplasticity in the brain reward system and the effects of brain stimulation on neuroplasticity in psychiatric disorders including depression, addiction and attention deficits.[4]

During his postdoc at the NIH, Zangen was part of a team that invented a magnetic coil called the "H coil" for use in transcranial magnetic stimulation (TMS); the coil allows deeper penetration of the magnetic field into the brain and the procedure wherein the H-coil was applied to TMS became known as "deep TMS".[1][5][6][7] The H-coil was patented by the NIH in 2002, and was licensed by the startup company Brainsway in 2003.[8][9] He has continued to do research on applications for deep TMS.[4][10]

In 2003, Zangen returned to Israel and established a laboratory at the Weizmann Institute of Science, where he attained the rank of associate professor in 2010. In 2012 he joined the faculty of Ben-Gurion University of the Negev as an associate professor and was made a full professor in 2015.[2]

The MIT Technology Review reported that Zangen and his team were evaluating the potential for disrupting areas of the brain that are overactive in cases of addiction or Obsessive compulsive disorder (OCD).[11]

In 2018, the FDA granted de novo clearance to deep transcranial magnetic stimulation as a non-invasive treatment for OCD, after being cleared for treatment-resistant major depressive disorder in 2013.[12]

In 2020, the FDA granted clearance for a different version of this technology for smoking cessation.[13]

Awards and recognition

Zangen has won prizes for his scientific achievements,[14][15]among them the Medical Futures Innovation Award in the field of Mental Health and Neuroscience, UK, in 2007,[16] the Sieratzki Prize for Advances in Neuroscience in 2010,[17] the Juludan Research Prize in 2015 [18]and the annual Innovation Award of Ben Gurion University in 2019.[19]

Selected papers
  • Zangen, Abraham; Ikemoto, Satoshi; Zadina, James E.; Wise, Roy A. (2002-08-15). "Rewarding and Psychomotor Stimulant Effects of Endomorphin-1: Anteroposterior Differences within the Ventral Tegmental Area and Lack of Effect in Nucleus Accumbens". Journal of Neuroscience. 22 (16): 7225–7233. doi:10.1523/jneurosci.22-16-07225.2002. PMID 12177217.
  • Zangen, Abraham; Solinas, Marcello; Ikemoto, Satoshi; Goldberg, Steven R.; Wise, Roy A. (2006-05-03). "Two Brain Sites for Cannabinoid Reward". Journal of Neuroscience. 26 (18): 4901–4907. doi:10.1523/JNEUROSCI.3554-05.2006. PMID 16672664.
  • Zangen, Abraham; Roth, Yiftach; Voller, Bernhard; Hallett, Mark. "Transcranial magnetic stimulation of deep brain regions: evidence for efficacy of the H-Coil". Clinical Neurophysiology. 116 (4): 775–779. doi:10.1016/j.clinph.2004.11.008. PMID 15792886.
  • Dinur-Klein, Limor; Dannon, Pinhas; Hadar, Aviad; Rosenberg, Oded; Roth, Yiftach; Kotler, Moshe; Zangen, Abraham. "Smoking Cessation Induced by Deep Repetitive Transcranial Magnetic Stimulation of the Prefrontal and Insular Cortices: A Prospective, Randomized Controlled Trial". Biological Psychiatry. 76 (9): 742–749. doi:10.1016/j.biopsych.2014.05.020. PMID 25038985.
  • Carmi, Lior; Alyagon, Uri; Barnea-Ygael, Noam; Zohar, Joseph; Dar, Reuven; Zangen, Abraham. "Clinical and electrophysiological outcomes of deep TMS over the medial prefrontal and anterior cingulate cortices in OCD patients". Brain Stimulation. 11 (1): 158–165. doi:10.1016/j.brs.2017.09.004. PMID 28927961.
  • Levkovitz, Yechiel; Isserles, Moshe; Padberg, Frank; Lisanby, Sarah H.; Bystritsky, Alexander; Xia, Guohua; Tendler, Aron; Daskalakis, Zafiris J.; Winston, Jaron L. (2015-02-01). "Efficacy and safety of deep transcranial magnetic stimulation for major depression: a prospective multicenter randomized controlled trial". World Psychiatry. 14 (1): 64–73. doi:10.1002/wps.20199. PMC 4329899. PMID 25655160.
  • Naim-Feil, Jodie; Zangen, Abraham (2013). "Chapter 49: Addiction". In Lozano, Andres M.; Hallett, Mark (eds.). Brain Stimulation. Elsevier Inc. ISBN 9780128080559.

See also

References
  1. Rapp, David (17 February 2005). "Field of Dreams". Haaretz.
  2. "CV and Publications". Zangen lab at Ben-Gurion University of the Negev. Archived from the original on 20 January 2018. Retrieved 20 January 2018.
  3. Helmet for a Good Head, Makor Rishon
  4. Abraham Zangen's Lab
  5. Bersani, F.S.; Minichino, A.; Enticott, P.G.; Mazzarini, L.; Khan, N.; Antonacci, G.; Raccah, R.N.; Salviati, M.; Chiai e, R. Delle. "Deep transcranial magnetic stimulation as a treatment for psychiatric disorders: A comprehensive review". European Psychiatry. 28 (1): 30–39. doi:10.1016/j.eurpsy.2012.02.006. PMID 22559998.
  6. George, Mark S. (September 2003). "Stimulating the Brain". Scientific American. 289 (3): 66–73. doi:10.1038/scientificamerican0903-66.
  7. "A Beautiful Magnetic Mind". Weizmann Weizmann Institute of Science Wonder Wander. 1 May 2005.
  8. Blackburn, Nicky (19 February 2006). "Israel's Brainsway stimulates a magnetic remedy for depression". Israel21c. Retrieved 11 January 2013.
  9. "Magnetic Stimulation Shows Promise as the New Wave for Treating Depression". NIH Office of Technology Transfer. 24 July 2007. Archived from the original on 30 March 2013.
  10. Chu, Jennifer (May 19, 2008). "A Gentler Way to Jump-Start the Brain". MIT Technology Review.
  11. A gentler way to jumpstart the brain, MIT Technology Review
  12. US FDA clears first magnetic non-invasive device treatment for OCD
  13. FDA clears first brain stimulation device for smoking cessation
  14. "Dr. Abraham Zangen - News, Features and Discoveries from the Weizmann Institute of Science". Weizmann Wonder Wander. 2007-09-02. Retrieved 2018-01-04.
  15. "Ben-Gurion University of the Negev - Prof. Abraham Zangen wins Juludan Research Prize". in.bgu.ac.il. Retrieved 2018-01-04.
  16. Weizmann Wonder Wander
  17. The Sieratzki Family and Tel Aviv University: Prize Winners
  18. Prof. Abraham Zangen wins Juludan Research Prize
  19. פרס מחקר יישומי פורץ דרך לפרופ' אברהם צנגן
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