Acetyl-S-ACP:malonate ACP transferase

Acetyl-S-ACP:malonate ACP transferase (EC 2.3.1.187, acetyl-S-ACP:malonate ACP-SH transferase, acetyl-S-acyl-carrier protein:malonate acyl-carrier-protein-transferase, MdcA, MadA, ACP transferase, malonate/acetyl-CoA transferase, malonate:ACP transferase, acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase) is an enzyme with systematic name acetyl-(acyl-carrier-protein):malonate S-(acyl-carrier-protein)transferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

acetyl-[acyl-carrier protein] + malonate malonyl-[acyl-carrier protein] + acetate
Acetyl-S-ACP:malonate ACP transferase
Identifiers
EC number2.3.1.187
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This is the first step in the catalysis of malonate decarboxylation.

References
  1. Hilbi H, Dimroth P (1994). "Purification and characterization of a cytoplasmic enzyme component of the Na+-activated malonate decarboxylase system of Malonomonas rubra: acetyl-S-acyl carrier protein: malonate acyl carrier protein-SH transferase". Archives of Microbiology. 162 (1–2): 48–56. doi:10.1007/bf00264372. PMID 18251085.
  2. Hoenke S, Schmid M, Dimroth P (June 1997). "Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli". European Journal of Biochemistry. 246 (2): 530–8. doi:10.1111/j.1432-1033.1997.00530.x. PMID 9208947.
  3. Koo JH, Kim YS (December 1999). "Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus". European Journal of Biochemistry. 266 (2): 683–90. doi:10.1046/j.1432-1327.1999.00924.x. PMID 10561613.
  4. Chohnan S, Akagi K, Takamura Y (January 2003). "Functions of malonate decarboxylase subunits from Pseudomonas putida". Bioscience, Biotechnology, and Biochemistry. 67 (1): 214–7. doi:10.1271/bbb.67.214. PMID 12619701.
  5. Dimroth P, Hilbi H (July 1997). "Enzymic and genetic basis for bacterial growth on malonate". Molecular Microbiology. 25 (1): 3–10. doi:10.1046/j.1365-2958.1997.4611824.x. PMID 11902724.
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