adipocyte protein 2

aP2 (adipocyte Protein 2)[5] is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking this protein either through genetic engineering or drugs[6] has the possibility of treating heart disease and the metabolic syndrome.[7]

FABP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NNT, 1TOU, 1TOW, 2HNX, 2NNQ, 3FR2, 3FR4, 3FR5, 3P6C, 3P6D, 3P6E, 3P6F, 3P6G, 3P6H, 3Q6L, 3RZY, 4NNS, 5EDB, 5EDC, 5D48, 5D4A, 5D45, 5D47
Identifiers
Aliases	FABP4, A-FABP, AFABP, ALBP, HEL-S-104, aP2, fatty acid binding protein 4
External IDs	OMIM: 600434 MGI: 88038 HomoloGene: 36067 GeneCards: FABP4
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.13 Start 81,478,419 bp[1] End 81,483,236 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 A1|3 2.56 cM Start 10,204,088 bp[2] End 10,208,576 bp[2]
Gene ontology Molecular function • transporter activity • fatty acid binding • lipid binding • GO:0005325 long-chain fatty acid transporter activity • long-chain fatty acid binding • hormone receptor binding Cellular component • cytosol • lipid droplet • extracellular exosome • cell nucleus • cytoplasm Biological process • white fat cell differentiation • regulation of inflammatory response • cytokine production • cholesterol homeostasis • positive regulation of inflammatory response • negative regulation of transcription, DNA-templated • cellular response to lithium ion • negative regulation of protein kinase activity • brown fat cell differentiation • triglyceride catabolic process • cellular response to tumor necrosis factor • transport • response to bacterium • long-chain fatty acid transport • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2167	11770
Ensembl	ENSG00000170323	ENSMUSG00000062515
UniProt	P15090	P04117
RefSeq (mRNA)	NM_001442	NM_024406
RefSeq (protein)	NP_001433	NP_077717
Location (UCSC)	Chr 8: 81.48 – 81.48 Mb	Chr 3: 10.2 – 10.21 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Fatty acid-binding protein

References

1. GRCh38: Ensembl release 89: ENSG00000170323 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062515 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Baxa CA, Sha RS, Buelt MK, Smith AJ, Matarese V, Chinander LL, Boundy KL, Bernlohr DA (1989). "Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA". Biochemistry. 28 (22): 8683–90. doi:10.1021/bi00448a003. PMID 2481498.
6. Floresta G, Pistarà V, Amata E, Dichiara M, Marrazzo A, Prezzavento O, Rescifina A (September 2017). "Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review". European Journal of Medicinal Chemistry. 138: 854–873. doi:10.1016/j.ejmech.2017.07.022. PMID 28738306.
7. Furuhashi M (March 2019). "Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases". Review. Journal of Atherosclerosis and Thrombosis. 26 (3): 216–232. doi:10.5551/jat.48710. PMC 6402888. PMID 30726793.

External links

• FABP4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human FABP4 genome location and FABP4 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Fatty acid-binding protein, adipocyte
• PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Fatty acid-binding protein, adipocyte