Alcoholic ketoacidosis

Alcoholic ketoacidosis (AKA) is a specific group of symptoms and metabolic state related to alcohol use.[3] Symptoms often include abdominal pain, vomiting, agitation, a fast respiratory rate, and a specific "fruity" smell.[2] Consciousness is generally normal.[1] Complications may include sudden death.[1]

Alcoholic ketoacidosis
Other names	Alcoholic ketosis, alcoholic acidosis[1]
It generally occurs in chronic alcoholics or those who binge drink[2]
Specialty	Internal medicine
Symptoms	Abdominal pain, vomiting, agitation, fast respiratory rate, specific "fruity" smell[2]
Risk factors	Alcoholism, binge drinking[2]
Diagnostic method	Based on symptoms[2]
Differential diagnosis	Other causes of high anion gap metabolic acidosis (diabetic ketoacidosis, toxic alcohol ingestion, starvation ketosis), pancreatitis[2][3]
Treatment	Intravenous fluids, thiamine[2]
Prognosis	Good with treatment[1]

AKA most commonly occurs in long term alcoholics and less commonly in those who binge drink.[2] Onset is generally after a decreased ability to eat for a few days.[2] Diagnosis is generally based on symptoms.[2] Blood sugar levels are often normally or only mildly increased.[2] Other conditions that may present similarly include other causes of high anion gap metabolic acidosis including diabetic ketoacidosis.[2]

Treatment is generally with intravenous normal saline and intravenous sugar solution.[2] Thiamine and measures to prevent alcohol withdrawal are also recommended.[2] Treatment of low blood potassium may also be required.[2] Those who are affected are most frequently between the ages of 20 and 60.[2] The condition was initially recognized in 1940 and named in 1971.[3]

Signs and symptoms

Nausea, vomiting, and abdominal pain are commonly present and people may also have tachypnea, tachycardia, and hypotension.[4] In contrast to diabetic ketoacidosis, people with alcoholic ketoacidosis are usually alert and lucid despite the severity of the acidosis.[1]

Causes

Alcoholic ketoacidosis is caused by complex physiology that is the result of prolonged and heavy alcohol intake, usually in the setting of poor nutrition. Chronic alcohol use can cause depleted hepatic glycogen stores and ethanol metabolism further impairs gluconeogenesis. This can reduce glucose availability and lead to hypoglycemia and increased reliance on fatty acid and ketone metabolism.[1][5] An additional stressor such as vomiting or dehydration can cause an increase in counterregulatory hormones such as glucagon, cortisol and growth hormone which may further increase free fatty acid release and ketone production. Ethanol metabolism can also increase blood lactic acid levels which may also contribute to a metabolic acidosis.[6]

Diagnosis

Diagnosis is generally based on symptoms.[2] An elevated anion gap metabolic acidosis and ketosis is the classic present.[3] However, a mixed acid-base disorder may be present especially if vomiting is contributing to a hypochloremic alkalosis.[2] The ketone which is present is mostly beta-hydroxybutryate rather than acetoacetate resulting in only a weakly positive nitroprusside test.[2] People usually do not present with high blood sugar or sugar in the urine.[2] This can cause false negative results when testing urine ketones as they only measure acetoacetate. Ethanol level are often low or negative despite a chronic alcohol use history.[6] Electrolyte disturbances may include hypokalemia or hypomagnesemia may also be present.[2]

Differential diagnosis

Other conditions that may present similarly include other causes of high anion gap metabolic acidosis such as diabetic ketoacidosis, toxic alcohol ingestion, and starvation ketosis.[2] Toxic alcohol ingestion include methanol and ethylene glycol poisoning.[6] Pancreatitis, alcoholic hepatitis, and gastritis may also result in similar symptoms.[3] The ratio of beta-hydroxybutryate to acetoacetate is usually higher in AKA (8:1) in contrast to diabetic ketoacidosis (3:1).[2]

Management

Treatment includes administration of intravenous saline to rehydrate and 5% dextrose to turn off gluconeogenesis. Electrolyte imbalances, specifically hypokalaemia, should be corrected. Thiamine supplementation is often included to prevent Wernicke encephalopathy. Insulin is generally not used due to risk of hypoglycemia.[5] Other potential causes of the symptoms should be ruled out.[6]

Prognosis

Outcomes are generally favorable with treatment but up to 10% may develop cardiac arrest.[5] It is proposed that alcoholic ketoacidosis is a significant cause of death among people with chronic alcoholism although the true prevalence is unknown. Estimation of prevalence and outcomes of this population is limited by difficulty in diagnosing the condition and the presence of multiple disorders at presentation.[6]

History

In 1940, Edward S. Dillon, W. Wallace, and Leon S. Smelo, first described alcoholic ketoacidosis as a distinct syndrome. They stated that "because of the many and complex factors, both physiologic and pathologic, which influence the acid-base balance of the body, a multitude of processes may bring about the state of acidosis as an end result."[7]

In 1971, David W. Jenkins and colleagues described cases of three non‐diabetic people with a history of chronic heavy alcohol misuse and recurrent episodes of ketoacidosis. This group also proposed a possible underlying mechanism for this metabolic disturbance, naming it alcoholic ketoacidosis.[8]

References

1. McGuire, LC; Cruickshank, AM; Munro, PT (June 2006). "Alcoholic ketoacidosis". Emergency Medicine Journal. 23 (6): 417–20. doi:10.1136/emj.2004.017590. PMC 2564331. PMID 16714496.
2. Howard, RD; Bokhari, SRA (January 2019). Alcoholic Ketoacidosis (AKA). PMID 28613672.
3. Allison, MG; McCurdy, MT (May 2014). "Alcoholic metabolic emergencies". Emergency Medicine Clinics of North America. 32 (2): 293–301. doi:10.1016/j.emc.2013.12.002. PMID 24766933.
4. Wrenn, KD; Slovis, CM; Minion, GE; Rutkowski, R (August 1991). "The syndrome of alcoholic ketoacidosis". The American Journal of Medicine. 91 (2): 119–28. doi:10.1016/0002-9343(91)90003-g. PMID 1867237.
5. Cartwright, Martina M.; Hajja, Waddah; Al-Khatib, Sofian; Hazeghazam, Maryam; Sreedhar, Dharmashree; Li, Rebecca Na; Wong-McKinstry, Edna; Carlson, Richard W. (Oct 2012). "Toxigenic and Metabolic Causes of Ketosis and Ketoacidotic Syndromes". Critical Care Clinics. 28 (4): 601–631. doi:10.1016/j.ccc.2012.07.001. PMID 22998993.
6. Höjer, Jonas (Oct 2017). "[Alcoholic ketoacidosis – a review]". Lakartidningen. 114. ISSN 1652-7518. PMID 28994854.
7. Dillon, E.; Dyer, W. Wallace; Smelo, L. S. (November 1940). "Ketone Acidosis in Nondiabetic Adults". Medical Clinics of North America. 24 (6): 1813–1822. doi:10.1016/S0025-7125(16)36653-6.
8. Jenkins, David W.; Eckel, Robert E.; Craig, James W. (12 July 1971). "Alcoholic Ketoacidosis". JAMA: The Journal of the American Medical Association. 217 (2): 177. doi:10.1001/jama.1971.03190020037007.

External links

Classification	D
External resources	eMedicine: med/102