Andrej Šali

Andrej Šali (born 1963, Kranj, Slovenia) is a computational structural biologist. Since 2003, he has been Professor in the Department of Bioengineering and Therapeutic Sciences at University of California, San Francisco.[1] He also serves as an editor of the journal Structure.

Andrej Šali
Andrej Šali speaking at ISMB 2012.
Alma mater	Birkbeck College, University of London
Scientific career
Institutions	University of California, San Francisco Harvard University Rockefeller University Birkbeck College, University of London University of Ljubljana
Thesis	Modelling three-dimensional structure of a protein from its amino acid sequence (1991)
Doctoral advisor	Tom Blundell
Notable students	Ilya Vakser Roberto Sanchez Andras Fiser Bino John Maya Topf Francisco Melo M.S. Madhusudhan Frank Alber Rachel Karchin Dmitry Korkin David Barkan
Website	www.salilab.org

Education

Šali received his Bachelor of Science degree in Chemistry from University of Ljubljana, 1987; his Ph.D. in Molecular Biophysics from Birkbeck College,[2] University of London, 1991 (working with Tom Blundell); and did postdoctoral work at Harvard University (working with Martin Karplus).

Research

Sali joined the faculty of the Rockefeller University in 1995, following his postdoctoral research at Harvard University. He is using computation grounded in the laws of physics and evolution to study the structure and function of proteins. For example, he developed comparative protein structure modeling by satisfaction of spatial restraints, implemented in program MODELLER[3] and integrative structure determination of macromolecular assemblies, implemented in program IMP.[4]

Research impact

Sali contributes greatly to structural biology by developing and applying computational methods for structural modeling and analysis of proteins. The two most often used programs developed by his research group include MODELLER for comparative protein structure modeling and IMP for integrative structure determination.

As of June 2017, Šali published approximately 370 papers,[5] which were cited approximately 56,000 times per Google Scholar. His Hirsch-index is 104 (i.e., 104 publication have been cited at least 104 times).

In 2018, Šali was elected member of the National Academy of Sciences in recognition of his contributions to biophysics and computational biology.[6]

Notable alumni from Šali Lab

Name	Lab Position	Duration	Current Location	Current Position
Frank Alber	Postdoctoral Fellow		University of California, Los Angeles, California, USA	Professor
Andras Fiser	Postdoctoral Fellow	Sep 1997 to Dec 2002	Albert Einstein College of Medicine, Bronx, NY	Professor
Rachel Karchin	Postdoctoral Fellow	Aug 2003 to Aug 2006	Johns Hopkins University	Associate Professor
Marc A. Marti-Renom	Postdoctoral Fellow Adjunct Assistant Professor	Feb 1999 to Jun 2006	National Center for Genomic Analysis (CNAG), Barcelona, Spain	Group Leader
M.S. Madhusudhan	Postdoctoral Scholar	Feb 2000 to Mar 2008	IISER, Pune, India	Associate Professor
David Barkan	Ph.D. Student	Sept 2006 to Oct 2011	Protagonist Therapeutics	Staff Scientist

References

1. List of publications from Microsoft Academic
2. Sali, Andrej (1984). Modelling three-dimensional structure of a protein from its amino acid sequence (PhD thesis). London, Birkbeck College.
3. Šali, A.; Blundell, T. L. (1993). "Comparative Protein Modelling by Satisfaction of Spatial Restraints". Journal of Molecular Biology. 234 (3): 779–815. doi:10.1006/jmbi.1993.1626. PMID 8254673.
4. Russel, D.; Lasker, K.; Webb, B.; Velázquez-Muriel, J.; Tjioe, E.; Schneidman-Duhovny, D.; Peterson, B.; Sali, A. (2012). "Putting the Pieces Together: Integrative Modeling Platform Software for Structure Determination of Macromolecular Assemblies". PLOS Biology. 10 (1): e1001244. doi:10.1371/journal.pbio.1001244. PMC 3260315. PMID 22272186.
5. Andrej Šali’s Publications
6. "Andrej Sali". National Academy of Sciences. Retrieved 2018-07-23.

External links

• Homepage of Šali's laboratory