C8 complex
High Resolution Crystal Structure of Human Complement Component 8[1]
| complement component 8, alpha polypeptide | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | C8A | ||||||
| NCBI gene | 731 | ||||||
| HGNC | 1352 | ||||||
| OMIM | 120950 | ||||||
| RefSeq | NM_000562 | ||||||
| UniProt | P07357 | ||||||
| Other data | |||||||
| Locus | Chr. 1 p36.2-22.1 | ||||||
| |||||||
| complement component 8, beta polypeptide | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | C8B | ||||||
| NCBI gene | 732 | ||||||
| HGNC | 1353 | ||||||
| OMIM | 1209660 | ||||||
| RefSeq | NM_000066 | ||||||
| UniProt | P073o58 | ||||||
| Other data | |||||||
| Locus | Chr. 1 p36.2-22.1 | ||||||
| |||||||
| complement component 8, gamma polypeptide | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | C8G | ||||||
| NCBI gene | 733 | ||||||
| HGNC | 1354 | ||||||
| OMIM | 120930 | ||||||
| RefSeq | NM_000606 | ||||||
| UniProt | P07360 | ||||||
| Other data | |||||||
| Locus | Chr. 9 q34.3 | ||||||
| |||||||
Membrane attack complex. Some labels are in Polish.
Structure
C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.
References
- PDB: 3OJY; Lovelace LL, Cooper CL, Sodetz JM, Lebioda L (May 2011). "Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement". The Journal of Biological Chemistry. 286 (20): 17585–92. doi:10.1074/jbc.M111.219766. PMC 3093833. PMID 21454577.
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