CDK5RAP3

CDK5 regulatory subunit-associated protein 3 is a protein that in humans is encoded by the CDK5RAP3 gene.[5][6]

CDK5RAP3
Identifiers
Aliases	CDK5RAP3, C53, HSF-27, IC53, LZAP, MST016, OK/SW-cl.114, PP1553, CDK5 regulatory subunit associated protein 3
External IDs	OMIM: 608202 MGI: 1933126 HomoloGene: 12718 GeneCards: CDK5RAP3
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 47,967,810 bp[1] End 47,981,781 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 96,907,426 bp[2] End 96,916,496 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • MDM2/MDM4 family protein binding • NF-kappaB binding • mitogen-activated protein kinase binding • GO:0001948 protein binding • ubiquitin-like protein ligase binding • protein kinase binding • cyclin binding Cellular component • cytoplasm • centrosome • membrane • microtubule organizing center • nucleolus • microtubules • cytoskeleton • endomembrane system • cell nucleus • cytosol • macromolecular complex Biological process • negative regulation of protein phosphorylation • regulation of neuron differentiation • protein ufmylation • positive regulation of signal transduction by p53 class mediator • regulation of phosphatase activity • endoplasmic reticulum unfolded protein response • mitotic G2/M transition checkpoint • negative regulation of cellular protein catabolic process • brain development • apoptotic nuclear changes • negative regulation of MAP kinase activity • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process • negative regulation of protein kinase activity by regulation of protein phosphorylation • negative regulation of protein serine/threonine kinase activity • cellular proliferation • mitotic G2 DNA damage checkpoint • negative regulation of NF-kappaB transcription factor activity • positive regulation of protein ubiquitination • positive regulation of transcription from RNA polymerase II promoter • positive regulation of protein localization to nucleus • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80279	80280
Ensembl	ENSG00000108465	ENSMUSG00000018669
UniProt	Q96JB5	Q99LM2
RefSeq (mRNA)	NM_001278197 NM_001278198 NM_001278216 NM_001278217 NM_025197 NM_176095 NM_176096	NM_030248 NM_001308183 NM_001363255 NM_001363256
RefSeq (protein)	NP_001265126 NP_001265127 NP_001265145 NP_001265146 NP_788276	NP_001295112 NP_084524 NP_001350184 NP_001350185
Location (UCSC)	Chr 17: 47.97 – 47.98 Mb	Chr 11: 96.91 – 96.92 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000108465 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018669 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ching YP, Qi Z, Wang JH (Apr 2000). "Cloning of three novel neuronal Cdk5 activator binding proteins". Gene. 242 (1–2): 285–94. doi:10.1016/S0378-1119(99)00499-0. PMID 10721722.
6. "Entrez Gene: CDK5RAP3 CDK5 regulatory subunit associated protein 3".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wang X, Ching YP, Lam WH, et al. (2000). "Identification of a common protein association region in the neuronal Cdk5 activator". J. Biol. Chem. 275 (41): 31763–9. doi:10.1074/jbc.M004358200. PMID 10915792.
• Ching YP, Pang AS, Lam WH, et al. (2002). "Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor". J. Biol. Chem. 277 (18): 15237–40. doi:10.1074/jbc.C200032200. PMID 11882646.
• Chen J, Liu B, Liu Y, et al. (2002). "A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart". Biochem. Biophys. Res. Commun. 294 (1): 161–6. doi:10.1016/S0006-291X(02)00446-1. PMID 12054757.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Xie YH, He XH, Tang YT, et al. (2003). "Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein". Cell Res. 13 (2): 83–91. doi:10.1038/sj.cr.7290153. PMID 12737517. S2CID 22264922.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Cen H, Zheng S, Fang YM, et al. (2004). "Induction of HSF1 expression is associated with sporadic colorectal cancer". World J. Gastroenterol. 10 (21): 3122–6. doi:10.3748/wjg.v10.i21.3122. PMC 4611254. PMID 15457556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jiang H, Luo S, Li H (2005). "Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint". J. Biol. Chem. 280 (21): 20651–9. doi:10.1074/jbc.M413431200. PMID 15790566.
• Yin X, Warner DR, Roberts EA, et al. (2005). "Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53". Int. J. Mol. Med. 16 (2): 251–6. doi:10.3892/ijmm.16.2.251. PMID 16012757.
• Wang J, He X, Luo Y, Yarbrough WG (2006). "A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2". Biochem. J. 393 (Pt 2): 489–501. doi:10.1042/BJ20050960. PMC 1360699. PMID 16173922.
• Kim E, Chen F, Wang CC, Harrison LE (2006). "CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation". Int. J. Oncol. 28 (1): 191–4. doi:10.3892/ijo.28.1.191. PMID 16327995.
• Camargo LM, Collura V, Rain JC, et al. (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia". Mol. Psychiatry. 12 (1): 74–86. doi:10.1038/sj.mp.4001880. PMID 17043677.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Stav D, Bar I, Sandbank J (2007). "Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma". Int. J. Biol. Markers. 22 (2): 108–13. doi:10.5301/jbm.2008.3142. PMID 17549666.
• Wang J, An H, Mayo MW, et al. (2007). "LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB". Cancer Cell. 12 (3): 239–51. doi:10.1016/j.ccr.2007.07.002. PMID 17785205.

External links

• Human CDK5RAP3 genome location and CDK5RAP3 gene details page in the UCSC Genome Browser.