Canine coronavirus

Canine coronavirus (CCoV) is an enveloped, positive-sense, single-stranded RNA virus which is a member of the species Alphacoronavirus 1. It causes a highly contagious intestinal disease worldwide in dogs.[2] The infecting virus enters its host cell by binding to the APN receptor.[3] It was discovered in 1971 in Germany during an outbreak in sentry dogs.[2] The virus is a member of the genus Alphacoronavirus and subgenus Tegacovirus.[4]

Canine coronavirus
Canine coronavirus antigen (arrows) in canine lung tissue
Virus classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Nidovirales
Family: Coronaviridae
Genus: Alphacoronavirus
Species: Alphacoronavirus 1
Virus: Canine coronavirus
Strains[1]
  • Canine coronavirus type I
    • Canine coronavirus strain Elmo/02
  • Canine coronavirus type II
    • Canine coronavirus strain NTU336/F/2008

Canine enteric coronavirus

Pathology

The virus invades and replicates in the villi of the small intestine. Intestinal disease may be related to virus-induced apoptosis (programmed cell death) of cells of the epithelial mucosa of the small intestine.[5] Canine coronavirus was originally thought to cause serious gastrointestinal disease, but now most cases are considered to be very mild or without symptoms.[6] A more serious complication of canine coronavirus occurs when the dog is also infected with canine parvovirus. Coronavirus infection of the intestinal villi makes the cells more susceptible to parvovirus infection. This causes a much more severe disease than either virus can separately.[7] However, fatal intestinal disease associated with canine coronavirus without the presence of canine parvovirus is still occasionally reported.[8][9] This may be related to the high mutation rate of RNA positive stranded viruses, of which canine coronavirus is one.[2]

Symptoms, diagnosis, treatment, and control
See also: DA2PPC vaccine

The incubation period is one to three days.[7] The disease is highly contagious and is spread through the feces of infected dogs, who usually shed the virus for six to nine days, but sometimes for six months following infection.[6] Symptoms include diarrhea, vomiting, and anorexia. Diagnosis is through detection of virus particles in the feces. Treatment usually only requires medication for diarrhea, but more severely affected dogs may require intravenous fluids for dehydration. Fatalities are rare. The virus is destroyed by most available disinfectants. There is a vaccine available (ATCvet code: QI07AD11 (WHO)), and it is usually given to puppies, who are more susceptible to canine coronavirus, and to dogs that have a high risk of exposure, such as show dogs.[7]

Canine respiratory coronavirus

Recently, a second type of canine coronavirus (Group II) has been shown to cause respiratory disease in dogs.[10] Known as canine respiratory coronavirus (CRCoV) and found to be similar to strain OC43 of bovine and human coronaviruses, it was first isolated in the United Kingdom in 2003 from lung samples of dogs[11] and has since been found on the European mainland[12] and in Japan.[13] A serological study in 2006 has also shown antibodies to CRCoV to be present in dogs in Canada and the United States.[14] However, a retrospective study in Saskatchewan found that CRCoV may have been present there as far back as 1996.[13]

References
  1. "ICTV 9th Report (2011) Coronaviridae" (html). International Committee on Taxonomy of Viruses (ICTV). Retrieved 10 January 2019.
  2. Pratelli A (2006). "Genetic evolution of canine coronavirus and recent advances in prophylaxis". Vet Res. 37 (2): 191–200. doi:10.1051/vetres:2005053. PMID 16472519.
  3. Fehr AR, Perlman S (2015). Maier HJ, Bickerton E, Britton P (eds.). "Coronaviruses: an overview of their replication and pathogenesis". Methods in Molecular Biology. Springer. 1282: 1–23. doi:10.1007/978-1-4939-2438-7_1. ISBN 978-1-4939-2438-7. PMC 4369385. PMID 25720466. See Table 1.
  4. "Taxonomy browser (Canine coronavirus)". www.ncbi.nlm.nih.gov. Retrieved 1 March 2020.
  5. Ruggieri, A; Di Trani, L; Gatto, I; Franco, M; Vignolo, E; Bedini, B; Elia, G; Buonavoglia, C (2007). "Canine coronavirus induces apoptosis in cultured cells". Vet Microbiol. 121 (1–2): 64–72. doi:10.1016/j.vetmic.2006.12.016. PMID 17254720.
  6. Pratelli, A. (2005). "Canine Coronavirus Infection". Recent Advances in Canine Infectious Diseases. Archived from the original on 10 April 2005. Retrieved 25 June 2006.
  7. Ettinger, Stephen J.; Feldman, Edward C. (1995). Textbook of Veterinary Internal Medicine (4th ed.). W.B. Saunders Company. ISBN 978-0-7216-6795-9.
  8. Evermann J, Abbott J, Han S (2005). "Canine coronavirus-associated puppy mortality without evidence of concurrent canine parvovirus infection". J Vet Diagn Invest. 17 (6): 610–4. doi:10.1177/104063870501700618. PMID 16475526.
  9. Buonavoglia C, Decaro N, Martella V, Elia G, Campolo M, Desario C, Castagnaro M, Tempesta M (2006). "Canine coronavirus highly pathogenic for dogs". Emerg Infect Dis. 12 (3): 492–4. doi:10.3201/eid1203.050839. PMC 3291441. PMID 16704791.
  10. Ellis, John A. (2006). "Outbreak! How can we approach emerging diseases?" (PDF). Proceedings of the North American Veterinary Conference. Archived from the original (PDF) on 29 September 2007. Retrieved 28 January 2007.
  11. Erles K, Toomey C, Brooks H, Brownlie J (2003). "Detection of a group 2 coronavirus in dogs with canine infectious respiratory disease". Virology. 310 (2): 216–23. doi:10.1016/S0042-6822(03)00160-0. PMID 12781709.
  12. Decaro N, Desario C, Elia G, Mari V, Lucente MS, Cordioli P, Colaianni ML, Martella V, Buonavoglia C (2006). "Serological and molecular evidence that canine respiratory coronavirus is circulating in Italy". Vet Microbiol. 121 (3–4): 225–30. doi:10.1016/j.vetmic.2006.12.001. PMID 17215093.
  13. Yachi A, Mochizuki M (2006). "Survey of dogs in Japan for group 2 canine coronavirus infection". J Clin Microbiol. 44 (7): 2615–8. doi:10.1128/JCM.02397-05. PMC 1489469. PMID 16825396.
  14. Priestnall S, Brownlie J, Dubovi E, Erles K (2006). "Serological prevalence of canine respiratory coronavirus". Vet Microbiol. 115 (1–3): 43–53. doi:10.1016/j.vetmic.2006.02.008. PMID 16551493.

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