Collagen, type XVI, alpha 1

Collagen alpha-1(XVI) chain is a protein that in humans is encoded by the COL16A1 gene.[5][6]

COL16A1
Identifiers
Aliases	COL16A1, 447AA, FP1572, collagen type XVI alpha 1, collagen type XVI alpha 1 chain
External IDs	OMIM: 120326 MGI: 1095396 HomoloGene: 1397 GeneCards: COL16A1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.2 Start 31,652,263 bp[1] End 31,704,319 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 130,047,840 bp[2] End 130,099,283 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • integrin binding • GO:0001948 protein binding • extracellular matrix structural constituent • extracellular matrix structural constituent conferring tensile strength Cellular component • extracellular region • collagen type XVI trimer • collagen • endoplasmic reticulum lumen • extracellular matrix • extracellular • collagen-containing extracellular matrix Biological process • cellular response to amino acid stimulus • integrin-mediated signaling pathway • female pregnancy • positive regulation of focal adhesion assembly • integrin activation • cell adhesion • extracellular matrix organization • cell adhesion mediated by integrin Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1307	107581
Ensembl	ENSG00000084636	ENSMUSG00000040690
UniProt	Q07092	Q8BLX7
RefSeq (mRNA)	NM_001856	NM_028266
RefSeq (protein)	NP_001847	NP_082542
Location (UCSC)	Chr 1: 31.65 – 31.7 Mb	Chr 4: 130.05 – 130.1 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000084636 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040690 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pan TC, Zhang RZ, Mattei MG, Timpl R, Chu ML (Aug 1992). "Cloning and chromosomal location of human alpha 1(XVI) collagen". Proc Natl Acad Sci U S A. 89 (14): 6565–9. Bibcode:1992PNAS...89.6565P. doi:10.1073/pnas.89.14.6565. PMC 49542. PMID 1631157.
6. "Entrez Gene: COL16A1 collagen, type XVI, alpha 1".

Further reading

• Yamaguchi N, Kimura S, McBride OW, Hori H, Yamada Y, Kanamori T, Yamakoshi H, Nagai Y (1993). "Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments". J. Biochem. 112 (6): 856–63. doi:10.1093/oxfordjournals.jbchem.a123989. PMID 1284248.
• Ratzinger S, Grässel S, Dowejko A, Reichert TE, Bauer RJ (2011). "Induction of type XVI collagen expression facilitates proliferation of oral cancer cells". Matrix Biology. 30 (2): 118–25. doi:10.1016/j.matbio.2011.01.001. PMID 21251976.
• Sires UI, Dublet B, Aubert-Foucher E, van der Rest M, Welgus HG (1995). "Degradation of the COL1 domain of type XIV collagen by 92-kDa gelatinase". J. Biol. Chem. 270 (3): 1062–7. doi:10.1074/jbc.270.3.1062. PMID 7836360.
• Tillet E, Mann K, Nischt R, Pan TC, Chu ML, Timpl R (1995). "Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain". Eur. J. Biochem. 228 (1): 160–8. doi:10.1111/j.1432-1033.1995.tb20245.x. PMID 7882999.
• Grässel S, Timpl R, Tan EM, Chu ML (1997). "Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells". Eur. J. Biochem. 242 (3): 576–84. doi:10.1111/j.1432-1033.1996.0576r.x. PMID 9022684.
• Ratzinger S, Grässel S, Dowejko A, Reichert TE, Bauer RJ (March 2011). "Induction of type XVI collagen expression facilitates proliferation of oral cancer cells". Matrix Biology. 30 (2): 118–25. doi:10.1016/j.matbio.2011.01.001. PMID 21251976.
• Kassner A, Hansen U, Miosge N, Reinhardt DP, Aigner T, Bruckner-Tuderman L, Bruckner P, Grässel S (2004). "Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils". Matrix Biol. 22 (2): 131–43. doi:10.1016/S0945-053X(03)00008-8. PMID 12782140.
• Kassner A, Tiedemann K, Notbohm H, Ludwig T, Mörgelin M, Reinhardt DP, Chu ML, Bruckner P, Grässel S (2004). "Molecular structure and interaction of recombinant human type XVI collagen". J. Mol. Biol. 339 (4): 835–53. doi:10.1016/j.jmb.2004.03.042. PMID 15165854.
• Eble JA, Kassner A, Niland S, Mörgelin M, Grifka J, Grässel S (2006). "Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains". J. Biol. Chem. 281 (35): 25745–56. doi:10.1074/jbc.M509942200. PMID 16754661.

External links

• "COL16A1 (collagen, type XVI, alpha 1)".