Cucumisin

Cucumisin (EC 3.4.21.25, euphorbain, solanain, hurain, tabernamontanain) is an enzyme.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

Hydrolysis of proteins with broad specificity
Cucumisin
Identifiers
EC number3.4.21.25
CAS number82062-89-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is isolated from the sarcocarp of the musk melon (Cucumis melo).

References
  1. Greenberg DM, Winnick T (1940). "Plant proteases. I. Activation-inhibition reactions". J. Biol. Chem. 135: 761–773.
  2. Jaffé WG (1943). "Hurain, a new plant protease from Hura crepitans". J. Biol. Chem. 149: 1–7.
  3. Jaffé WG (1943). "A new vegetable proteolytic enzyme of the papain class". Rev. Brasil Biol. 3: 149–157.
  4. Kaneda M, Tominaga N (December 1975). "Isolation and characterization of a proteinase from the sarcocarp of melon fruit". Journal of Biochemistry. 78 (6): 1287–96. PMID 5423.
  5. Kaneda M, Ohmine H, Yonezawa H, Tominaga N (March 1984). "Amino acid sequence around the reactive serine of cucumisin from melon fruit". Journal of Biochemistry. 95 (3): 825–9. PMID 6427203.
  6. Lynn KR, Clevette-Radford NA (1985). "Two proteases from the latex of Elaeophorbia drupifera". Phytochemistry. 24: 2843–2845. doi:10.1016/0031-9422(85)80011-x.
  7. Kaneda N, Minematsu Y, Powers JC, Tominaga N (1986). "Specificity of cucumisin in hydrolysis of peptide thiobenzyl esters". Agric. Biol. Chem. 50: 1075–1076. doi:10.1271/bbb1961.50.1075.
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