Diacylglycerol cholinephosphotransferase

In enzymology, a diacylglycerol cholinephosphotransferase (EC 2.7.8.2) is an enzyme that catalyzes the chemical reaction

CDP-choline + 1,2-diacylglycerol CMP + a phosphatidylcholine
diacylglycerol cholinephosphotransferase
Identifiers
EC number2.7.8.2
CAS number9026-13-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are CDP-choline and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylcholine.[1]

Classification

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups.

Nomenclature

The systematic name of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include:

  • 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase,
  • 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase,
  • 1-alkyl-2-acetylglycerol cholinephosphotransferase,
  • alkylacylglycerol choline phosphotransferase,
  • alkylacylglycerol cholinephosphotransferase,
  • CDP-choline diglyceride phosphotransferase,
  • cholinephosphotransferase,
  • CPT,
  • cytidine diphosphocholine glyceride transferase,
  • cytidine diphosphorylcholine diglyceride transferase,
  • diacylglycerol choline phosphotransferase,
  • phosphocholine diacylglyceroltransferase,
  • phosphorylcholine-glyceride transferase, and
  • sn-1,2-diacylglycerol cholinephosphotransferase.

Biological role

This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.

References
  1. Coleman R, Bell RM (1977). "Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities". J. Biol. Chem. 252 (9): 3050–6. PMID 192727.
  • Lee TC, Blank ML, Fitzgerald V, Snyder F (1982). "Formation of alkylacyl- and diacylglycerophosphocholines via diradylglycerol cholinephosphotransferase in rat liver". Biochim. Biophys. Acta. 713 (2): 479–83. doi:10.1016/0005-2760(82)90269-7. PMID 6295501.
  • Parthasarathy S, Cady RK, Kraushaar DS, Sladek NE, Baumann WJ (1978). "Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate". Lipids. 13 (2): 161–4. doi:10.1007/BF02533260. PMID 204847.
  • Renooij W, Snyder F (1981). "Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues". Biochim. Biophys. Acta. 663 (2): 545–56. doi:10.1016/0005-2760(81)90182-x. PMID 6260215.


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