Ephedra (plant)

Ephedra is a genus of gymnosperm shrubs, the only extant genus in its family, Ephedraceae, and order, Ephedrales. The various species of Ephedra are widespread in many lands, native to southwestern North America, southern Europe, northern Africa, southwest and central Asia, northern China and western South America.[3]

This article is about the genus Ephedra, and the family Ephedraceae. For the use of the plant in medicine, see Ephedra.

Ephedra
Temporal range: Aptian–Recent
Ephedra viridis
Scientific classification
Kingdom: Plantae
Clade: Tracheophytes
Division: Gnetophyta
Class: Gnetopsida
Order: Ephedrales
Dumort.[1]
Family: Ephedraceae
Dumort.[2]
Genus: Ephedra
L.[2]
Global range of Ephedra
Synonyms[3]

Alloephedra Tao JR et Yang Y., 2003. Chaetocladus Nelson 1866 nom. illeg. Liaoxia Cao et S.Q. Wu, 1996

In temperate climates, most Ephedra species grow on shores or in sandy soils with direct sun exposure. Common names in English include joint-pine, jointfir, Mormon-tea or Brigham tea. The Chinese name for Ephedra species is mahuang (simplified Chinese: 麻黄; traditional Chinese: 麻黃; pinyin: máhuáng; Wade–Giles: ma-huang; lit. 'hemp yellow').

Ephedra fragilis pollen cones
Ephedra distachya: ripe female cones with seeds
Ephedra ciliata seed

Description

The family, Ephedraceae Dumort., of which Ephedra is the only genus, are gymnosperms, and generally shrubs, sometimes clambering vines, and rarely, small trees. Members of the genus frequently spread by the use of rhizomes.[4]

The stems are green and photosynthetic.[5] The leaves are opposite or whorled. The scalelike leaves fuse into a sheath at the base and this often sheds soon after development. There are no resin canals.[4]

The plants are mostly dioecious: with the pollen strobili in whorls of 1-10, each consisting of a series of decussate[6] bracts. The pollen is furrowed. The female strobili also occur in whorls, with bracts which fuse around a single ovule. There are generally 1-2 yellow to dark brown seeds per strobilus.[4]

Distribution

The genus is found worldwide, in desert regions, but not in Australia[4]

Ecology
Shrubs of Ephedra major in Karvachar

Ephedraceae are adapted to extremely arid regions, growing often in high sunny habitats, and occur as high as 4000 m above sea level in both the Andes and the Himalayas.[4]

Taxonomy

The genus, Ephedra was first described in 1753 by L.,[7][8][9] and the type species is Ephedra distachya.[8] The family, Ephedraceae, was first described in 1829 by Dumortier.[7][10]

Medical uses
Plant as used in Chinese herbology (crude medicine)
Main article: Ephedra

Plants of the genus Ephedra, including E. sinica and others, have traditionally been used by indigenous people for a variety of medicinal purposes, including treatment of asthma, hay fever and the common cold.[11] The alkaloids ephedrine and pseudoephedrine are active constituents of E. sinica and other members of the genus. These compounds are sympathomimetics with stimulant and decongestant qualities and are chemically substituted amphetamines.

Pollen of Ephedra spp. was found in the Shanidar IV burial site in Iraq, which led to the suggestion that its use as a medicinal plant dates to over 60,000 years ago.[12] Paul B. Pettitt has stated that "[a] recent examination of the microfauna from the strata into which the grave was cut suggests that the pollen was deposited by the burrowing rodent Meriones persicus, which is common in the Shanidar microfauna and whose burrowing activity can be observed today".[13] It has been suggested that Ephedra may be the soma plant of Indo-Iranian religion.[14]

Adverse effects

Alkaloids obtained from the species of Ephedra used in herbal medicines, which are used to synthetically prepare pseudoephedrine and ephedrine, can cause cardiovascular events. These events have been associated with arrhythmias, palpitations, tachycardia and myocardial infarction. Caffeine consumption in combination with ephedrine has been reported to increase the risk of these cardiovascular events.[15]

Evolutionary history

The oldest known members of the genus are from the Early Cretaceous, with records being known from the Aptian-Albian of Argentina,[16]China,[17] Portugal and the United States.[18]

Species

Accepted species:[3]

  • Ephedra alata Decaisne 1824 – North Africa, Arabian Peninsula
  • Ephedra altissima Desfontaines 1799 non Bové 1834 non Delile 1813 non Buch 1828 – North Africa, Canary Islands
  • Ephedra americana Humboldt & Bonpland ex Willdenow 1806 – Bolivia, Ecuador, Peru, Argentina, Chile
  • Ephedra antisyphilitica Berland ex von Meyer 1845 – Clapweed, Erect Ephedra – Texas, Oklahoma, New Mexico, Nuevo León, Coahuila, Chihuahua
  • Ephedra aphylla Forsskål 1775 – eastern Mediterranean from Libya and Cyprus to the Persian Gulf
  • Ephedra × arenicola Cutler 1939 – Arizona, Utah (hybrid, E. cutleri × E. torreyana)
  • Ephedra aspera Engelmann ex Watson 1882 – Boundary Ephedra, Pitamoreal – Texas, New Mexico, Arizona, Utah, Nevada, California, Chihuahua, Durango, Zacatecas, Sinaloa, Sonora, Baja California
  • Ephedra aurantiaca Takhtajan & Pachomova 1967 – Caucasus, Kazakhstan, Turkmenistan
  • Ephedra boelckei F.A.Roig – Argentina
  • Ephedra botschantzevii Pachom. – Kazakhstan, Tuva region of Siberia
  • Ephedra breana Phil. – Peru, Bolivia, Chile, Argentina
  • Ephedra brevifoliata Ghahr. – Iran
  • Ephedra californica S.Wats. – California Ephedra, California Jointfir – California, western Arizona, Baja California
  • Ephedra chilensis C.Presl – Chile, Argentina
  • Ephedra compacta Rose – widespread in much of Mexico
  • Ephedra coryi E.L.Reed – Cory's Ephedra – Texas, New Mexico
  • Ephedra cutleri Peebles – Navajo Ephedra, Cutler's Ephedra, Cutler Mormon-tea, Cutler's Jointfir – Colorado, Utah, Arizona, New Mexico, Wyoming
  • Ephedra dahurica Turcz. – Siberia, Mongolia
  • Ephedra dawuensis Y.Yang – Sichuan
  • Ephedra distachya L. – Joint-pine, Jointfir – southern Europe and central Asia from Portugal to Kazakhstan
  • Ephedra × eleutherolepis V.A.Nikitin – Tajikistan (hybrid E. intermedia × E. strobilacea)
  • Ephedra equisetina Bunge – Ma huang – Caucasus, Central Asia, Siberia, Mongolia, Gansu, Hebei, Inner Mongolia, Ningxia, Qinghai, Shanxi, Xinjiang
  • Ephedra fasciculata A.Nelson – Arizona Ephedra, Arizona Jointfir, Desert Mormon-tea – Arizona, California, Nevada, Utah
  • Ephedra fedtschenkoae Paulsen – Central Asia, Siberia, Mongolia, Xinjiang
  • Ephedra foeminea Forssk. – North Africa, Somalia, Balkans, Italy, Middle East; naturalized in Santa Barbara County of California
  • Ephedra foliata Boiss. ex C.A.Mey. – North Africa, Somalia, Middle East, India
  • Ephedra fragilis Desf. – Mediterranean, Canary Islands, Madeira
  • Ephedra frustillata Miers – Patagonian Ephedra – Chile, Argentina
  • Ephedra funerea Coville & Morton – Death Valley Ephedra, Death Valley Jointfir – California, Arizona, Nevada
  • Ephedra gerardiana Wallich ex C.A.Meyer – Gerard's Jointfir, Shan Ling Ma Huang – Himalayas, Tibet, Yunnan, Siberia, Central Asia
  • Ephedra glauca Regel – Iran, Central Asia, Mongolia
  • Ephedra holoptera Riedl – Iran
  • Ephedra intermedia Schrenk & C.A.Meyer – China, Siberia, Central Asia, Himalayas, Iran, Pakistan
  • Ephedra × intermixta H.C.Cutler – New Mexico (hybrid E. trifurca × E. torreyana)
  • Ephedra kardangensis P.Sharma & P.L.Uniyal – western Himalayas
  • Ephedra khurikensis P.Sharma & P.L.Uniyal – western Himalayas
  • Ephedra laristanica Assadi – Iran
  • Ephedra lepidosperma C.Y.Cheng – northern China
  • Ephedra likiangensis Florin – Guizhou, Sichuan, Tibet, Yunnan
  • Ephedra lomatolepis Schrenk – Kazakhstan, Tuva region of Siberia
  • Ephedra major Host – Mediterranean, Middle East, Central Asia; from Canary Islands to Kashmir
  • Ephedra milleri Freitag & Maier-St. – Oman, Yemen
  • Ephedra minuta Florin – Qinghai, Sichuan
  • Ephedra monosperma C.A.Meyer – Siberia, Mongolia, much of China including Tibet and Xinjiang
  • Ephedra multiflora Phil. ex Stapf – Chile, Argentina
  • Ephedra nevadensis S.Wats. – Nevada Ephedra, Nevada Jointfir, Nevada Mormon-tea – Baja California, California, Arizona, Nevada, Utah, Oregon
  • Ephedra ochreata Miers – Argentina
  • Ephedra oxyphylla Riedl – Afghanistan
  • Ephedra pachyclada Boiss. – Middle East from Sinai and Yemen to Pakistan
  • Ephedra pedunculata Engelm. ex S.Wats. – Vine Ephedra, Vine Jointfir – Texas, Chihuahua, Coahuila, Durango, San Luis Potosí, Nuevo León, Zacatecas
  • Ephedra pentandra Pachom. – Iran
  • Ephedra przewalskii Stapf – Central Asia, Mongolia, Pakistan, Gansu, Inner Mongolia, Ningxia, Qinghai, Tibet
  • Ephedra pseudodistachya Pachom. – Siberia, Mongolia
  • Ephedra regeliana Florin – Xi Zi Ma Huang – Central Asia, Siberia, Pakistan, Xinjiang
  • Ephedra rhytidosperma Pachom. – Gansu, Inner Mongolia, Ningxia, Mongolia
  • Ephedra rituensis Y.Yang, D.Z.Fu & G.H.Zhu – Qinghai, Xinjiang, Tibet
  • Ephedra rupestris Benth. – Ecuador, Peru, Bolivia, Argentina
  • Ephedra sarcocarpa Aitch. & Hemsl. -Pakiostan, Afghanistan
  • Ephedra sinica Stapf – Cao Ma Huang, Chinese ephedra – Mongolia, Siberia, Primorye, Manchuria
  • Ephedra somalensis Freitag & Maier-St. – Somalia, Eritrea
  • Ephedra strobilacea Bunge – Iran, Central Asia
  • Ephedra sumlingensis P.Sharma & P.L.Uniyal – western Himalayas
  • Ephedra tilhoana Maire – Chad
  • Ephedra torreyana S.Wats. – Torrey's Ephedra, Torrey's Jointfir, Torrey's Mormon-tea, Cañutillo – Nevada, Utah, Colorado, Arizona, New Mexico, Texas, Chihuahua
  • Ephedra transitoria Riedl – Iraq, Syria, Palestine, Saudi Arabia
  • Ephedra triandra Tul. -Bolivia, Argentina
  • Ephedra trifurca Torrey ex S.Wats. – Longleaf Ephedra, Longleaf Jointfir, Longleaf Mormon-tea, Popotilla, Teposote – California, Arizona, New Mexico, Texas, Chihuahua, Sonora, Baja California
  • Ephedra tweedieana C.A.Mey. – Brazil, Argentina, Uruguay
  • Ephedra viridis Coville – Green Ephedra, Green Mormon-tea – California, Nevada, Utah, Arizona, New Mexico, Colorado, Wyoming, South Dakota, Oregon
  • Ephedra vvedenskyi Pachom. – Iran, Caucasus, Turkmenistan
  • Ephedra yangthangensis Prabha Sharma & Rita Singh – Yangthang to Ka, Leo, Nako, Chango, Chulling, Sumdo, Hoorling and Lira of Kinnaur district of Himachal Pradesh[19]

Economic botany and alkaloid content

Earliest uses of Ephedra spp. (mahuang) for specific illnesses date back to 5000 BC. Ephedrine and isomers were already isolated in 1881 from Ephedra dystachia and characterized by the Japanese organic chemist Nagai Nagayoshi of the 19th century. His work to access Ephedra drug materials to isolate a pure pharmaceutical substance, and the systematic production of semi-synthetic derivatives thereof is relevant still today as the three species Ephedra sinica, Ephedra vulgaris and to a lesser extent Ephedra equisetina are commercially grown in Mainland China as a source for natural ephedrines and isomers for use in pharmacy. E. sinica and E. vulgaris usually carry six optically active phenylethylamines, mostly ephedrine and pseudoephedrine with minor amounts of norephedrine, norpseudoephedrine as well as the three methylated analogs. Reliable information on the total alkaloid content of the crude drug is difficult to obtain. Based on HPLC analyses in industrial settings, the concentrations of total alkaloids in dried Herba Ephedra ranged between 1 and 4%, and in some cases up to 6%.[20]

For a review of the alkaloid distribution in different species of the genus Ephedra see Jian-fang Cui (1991).[21] Other American and European species of Ephedra, e.g. Ephedra nevadensis (Nevada Mormon tea) have not been systematically assayed; based on unpublished field investigations, they contain very low levels (less than 0.1%) or none at all.[22]

References
  1. "Ephedrales Dumort". EU-NOMEN. Retrieved 20 January 2016.
  2. Kramer KU, Green PS, Götz E (1990). Kramer KU, Green PS (eds.). The Families and Genera of Vascular Plants, Vol. 1: Pteridophytes and Gymnosperms. Berlin: Springer-Verlag. pp. 379–381. ISBN 3540517944.
  3. Kew World Checklist of Selected Plant Families
  4. Judd WS, Campbell CS, Kellog EA, Stevens PF, Donoghue MJ (2007). Plant Systematics, a phylogenetic approach (3rd. ed.). Sinauer associates, Inc.
  5. "Family "Ephedraceae"". Angiosperm Phylogeny Website. Retrieved 5 July 2019.
  6. Messina A (2014). "VicFlora: Ephedraceae". Victoria, Australia: Royal Botanic Gardens Foundation. Retrieved 5 July 2019.
  7. The Gymnosperm database: Ephedra. Retrieved 5 July 2019.
  8. Linnaeus C (1753). Species Plantarum. 2. p. 1040.
  9. Linnaeus C (1754). "Genera plantarum". p. 462.
  10. Dumortier BC (1829). Analyse des familles des plantes, avec l'indication des principaux genres qui s'y rattachent. Tournay: J. Casterman aîné. p. 11.
  11. Abourashed EA, El-Alfy AT, Khan IA, Walker L (August 2003). "Ephedra in perspective--a current review". Phytotherapy Research. 17 (7): 703–12. doi:10.1002/ptr.1337. PMID 12916063. S2CID 41083359.
  12. Solecki RS (1975). "Shanidar IV, a Neanderthal Flower Burial in Northern Iraq". Science. 190 (4217): 880–881. Bibcode:1975Sci...190..880S. doi:10.1126/science.190.4217.880. JSTOR 1741776. S2CID 71625677.
  13. Pettitt PB (2002). "The Neanderthal dead: exploring mortuary variability in Middle Palaeolithic Eurasia" (PDF). Before Farming. 1 (4): 1–26. doi:10.3828/bfarm.2002.1.4.
  14. Rudgley R (1993). The Alchemy of Culture. London: British Museum Press. pp. 44–45. ISBN 0-7141-2711-6.
  15. Skalli S, Zaid A, Soulaymani R (December 2007). "Drug interactions with herbal medicines". Therapeutic Drug Monitoring. 29 (6): 679–86. doi:10.1097/FTD.0b013e31815c17f6. PMID 18043467. S2CID 17042490.
  16. Puebla GG, Iglesias A, Gómez MA, Prámparo MB (November 2017). "Fossil record of Ephedra in the Lower Cretaceous (Aptian), Argentina". Journal of Plant Research. 130 (6): 975–988. doi:10.1007/s10265-017-0953-1. PMID 28528483. S2CID 23766815.
  17. Yang Y, Wang Q (2013-01-14). "The earliest fleshy cone of Ephedra from the early cretaceous Yixian Formation of northeast China". PLOS ONE. 8 (1): e53652. Bibcode:2013PLoSO...853652Y. doi:10.1371/journal.pone.0053652. PMC 3544918. PMID 23341964.
  18. Rydin C, Pedersen KR, Crane PR, Friis EM (July 2006). "Former diversity of Ephedra (Gnetales): evidence from Early Cretaceous seeds from Portugal and North America". Annals of Botany. 98 (1): 123–40. doi:10.1093/aob/mcl078. PMC 2803531. PMID 16675607.
  19. Sharma P, Singh R (December 2016). "Ephedra yangthangensis (Ephedraceae), a new species from Himachal Pradesh, India. Bangladesh". Journal of Plant Taxonomy. 23 (2): 195–8. doi:10.3329/bjpt.v23i2.30850.
  20. Brossi A, ed. (1989). The Alkaloids: Chemistry and Pharmacology. 35. ISBN 0-12-469535-3.
  21. Kim HK, Choi YH, Erkelens C, Lefeber AW, Verpoorte R (January 2005). "Metabolic fingerprinting of Ephedra species using 1H-NMR spectroscopy and principal component analysis". Chemical & Pharmaceutical Bulletin. 53 (1): 105–9. doi:10.1002/pca.2800020305. PMID 15635242.
  22. Hegnauer R. (1962) "Chemotaxonomie der Pflanzen. I". Birkhauser Verlag, Basel; Switzerland, pp. 460–462 as cited in Roman MC (2004). "Determination of ephedrine alkaloids in botanicals and dietary supplements by HPLC-UV: collaborative study". Journal of AOAC International. 87 (1): 1–14. doi:10.1093/jaoac/87.1.1. PMC 2584348. PMID 15084081.
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