Exosome component 6

Exosome complex exonuclease MTR3 is an enzyme that in humans is encoded by the EXOSC6 gene.[5][6][7]

EXOSC6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6
Identifiers
Aliases	EXOSC6, EAP4, MTR3, Mtr3p, hMtr3p, p11, Exosome component 6
External IDs	OMIM: 606490 MGI: 1919794 HomoloGene: 12469 GeneCards: EXOSC6
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 70,246,778 bp[1] End 70,251,940 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 111,056,339 bp[2] End 111,057,664 bp[2]
Gene ontology Molecular function • exoribonuclease activity • RNA binding Cellular component • cytoplasm • cytosol • exosome complex • nuclear exosome (RNase complex) • cytoplasmic exosome (RNase complex) • nucleolus • cell nucleus • nucleoplasm Biological process • regulation of mRNA stability • nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' • rRNA 3'-end processing • rRNA catabolic process • DNA deamination • nuclear mRNA surveillance • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • U4 snRNA 3'-end processing • polyadenylation-dependent snoRNA 3'-end processing • rRNA processing • positive regulation of isotype switching • isotype switching • RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	118460	72544
Ensembl	ENSG00000223496	ENSMUSG00000109941
UniProt	Q5RKV6	Q8BTW3
RefSeq (mRNA)	NM_058219	NM_028274
RefSeq (protein)	NP_478126	NP_082550
Location (UCSC)	Chr 16: 70.25 – 70.25 Mb	Chr 8: 111.06 – 111.06 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene product constitutes one of the subunits of the multisubunit particle called the exosome complex, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.[7]

Interactions

Exosome component 6 has been shown to interact with Exosome component 7,[6]Exosome component 8[6] and Exosome component 1.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000223496 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000109941 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (Nov 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.
6. Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J Mol Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
7. "Entrez Gene: EXOSC6 exosome component 6".

Further reading

• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• van Hoof A, Parker R (2002). "Messenger RNA degradation: beginning at the end". Curr. Biol. 12 (8): R285–7. doi:10.1016/S0960-9822(02)00802-3. PMID 11967169. S2CID 17142692.
• Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
• Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.