Exosome component 7

Exosome component 7, also known as EXOSC7, is a human gene, the protein product of which is part of the exosome complex.[5]

EXOSC7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6
Identifiers
Aliases	EXOSC7, EAP1, RRP42, Rrp42p, hRrp42p, p8, Exosome component 7
External IDs	OMIM: 606488 MGI: 1913696 HomoloGene: 8994 GeneCards: EXOSC7
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 44,975,241 bp[1] End 45,036,066 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F4 Start 123,113,215 bp[2] End 123,136,129 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • 3'-5'-exoribonuclease activity • exoribonuclease activity • GO:0001948 protein binding • RNA binding • AU-rich element binding Cellular component • cytoplasm • cytosol • exosome complex • nucleolus • nucleoplasm • cell nucleus • nuclear exosome (RNase complex) • cytoplasmic exosome (RNase complex) Biological process • regulation of mRNA stability • RNA catabolic process • rRNA processing • exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' • U1 snRNA 3'-end processing • U4 snRNA 3'-end processing • U5 snRNA 3'-end processing • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • nuclear mRNA surveillance • nuclear polyadenylation-dependent rRNA catabolic process • nuclear polyadenylation-dependent tRNA catabolic process • nuclear polyadenylation-dependent mRNA catabolic process • rRNA catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23016	66446
Ensembl	ENSG00000075914	ENSMUSG00000025785
UniProt	Q15024	Q9D0M0
RefSeq (mRNA)	NM_015004	NM_001081188
RefSeq (protein)	NP_055819	NP_001074657
Location (UCSC)	Chr 3: 44.98 – 45.04 Mb	Chr 9: 123.11 – 123.14 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Exosome component 7 has been shown to interact with:

• Exosome component 1,[6][7]
• Exosome component 2,[6] and
• Exosome component 6.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000075914 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025785 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: EXOSC7 exosome component 7".
6. Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/s0022-2836(02)00947-6. PMID 12419256.
7. Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (Jan 2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.

Further reading

• Butler JS (2002). "The yin and yang of the exosome". Trends Cell Biol. 12 (2): 90–6. doi:10.1016/S0962-8924(01)02225-5. PMID 11849973.
• Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
• Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
• Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
• Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome". Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549.
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.