FUCA2

Plasma alpha-L-fucosidase (see alpha-L-fucosidase) is an enzyme that in humans is encoded by the FUCA2 gene.[5][6]

FUCA2
Identifiers
Aliases	FUCA2, dJ20N2.5, fucosidase, alpha-L- 2, plasma, alpha-L-fucosidase 2
External IDs	OMIM: 136820 MGI: 1914098 HomoloGene: 119 GeneCards: FUCA2
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q24.2 Start 143,494,812 bp[1] End 143,511,720 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A2 Start 13,499,540 bp[2] End 13,519,035 bp[2]
Gene ontology Molecular function • hydrolase activity • alpha-L-fucosidase activity • hydrolase activity, acting on glycosyl bonds • GO:0001948 protein binding Cellular component • extracellular exosome • extracellular region • extracellular • azurophil granule lumen • endoplasmic reticulum lumen • lysosome Biological process • fucose metabolic process • metabolism • glycoside catabolic process • neutrophil degranulation • post-translational modification • cellular protein metabolic process • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2519	66848
Ensembl	ENSG00000001036	ENSMUSG00000019810
UniProt	Q9BTY2 Q7Z6V2	Q99KR8
RefSeq (mRNA)	NM_032020	NM_025799 NM_001330198
RefSeq (protein)	NP_114409	NP_001317127 NP_080075
Location (UCSC)	Chr 6: 143.49 – 143.51 Mb	Chr 10: 13.5 – 13.52 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000001036 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019810 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Eiberg H, Mohr J, Nielsen LS (Oct 1984). "Linkage of plasma alpha-L-fucosidase (FUCA2) and the plasminogen (PLG) system". Clin Genet. 26 (1): 23–9. doi:10.1111/j.1399-0004.1984.tb00782.x. PMID 6590153. S2CID 85371006.
6. "Entrez Gene: FUCA2 fucosidase, alpha-L- 2, plasma".

Further reading

• Narahara K, Tsuji K, Yokoyama Y, et al. (1991). "Specification of small distal 6q deletions in two patients by gene dosage and in situ hybridization study of plasminogen and alpha-L-fucosidase 2". Am. J. Med. Genet. 40 (3): 348–53. doi:10.1002/ajmg.1320400322. PMID 1951444.
• O'Brien JS, Willems PJ, Fukushima H, et al. (1988). "Molecular biology of the alpha-L-fucosidase gene and fucosidosis". Enzyme. 38 (1–4): 45–53. doi:10.1159/000469189. PMID 2894306.
• Cordero OJ, Merino A, Páez de la Cadena M, et al. (2001). "Cell surface human alpha-L-fucosidase". Eur. J. Biochem. 268 (11): 3321–31. doi:10.1046/j.1432-1327.2001.02237.x. PMID 11389735.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.