Fenpropathrin

Fenpropathrin (brand names Danitol, Meothrin), or fenopropathrin, is a widely used pyrethroid insecticide in agriculture and household.[1][2][3][4]

Fenpropathrin

Clinical data
ATC code	None
Identifiers
IUPAC name [Cyano-(3-phenoxyphenyl)methyl] 2,2,3,3-tetramethylcyclopropane-1-carboxylate
CAS Number	39515-41-8
PubChem CID	47326
ChemSpider	45352
UNII	87BH96P0MX
KEGG	C18411
CompTox Dashboard (EPA)	DTXSID0024002
ECHA InfoCard	100.049.514
Chemical and physical data
Formula	C22H23NO3
Molar mass	349.430 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CC1(C(C1(C)C)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C
InChI InChI=InChI=1S/C22H23NO3/c1-21(2)19(22(21,3)4)20(24)26-18(14-23)15-9-8-12-17(13-15)25-16-10-6-5-7-11-16/h5-13,18-19H,1-4H3 Key:XQUXKZZNEFRCAW-UHFFFAOYSA-N

A person developed Parkinson's disease after six months of daily exposure to fenpropathrin, and animal tests subsequently revealed that the compound is a dopaminergic neurotoxin.[4] It has thus been implicated as an environmental risk factor for Parkinson's disease.[4]

See also

• 6-Hydroxydopamine
• MPTP
• Norsalsolinol
• Rotenone

References

1. Aizawa H (2 December 2012). Metabolic Maps of Pesticides. Elsevier Science. pp. 185–. ISBN 978-0-323-15753-7.
2. Abou-Donia MB (15 July 1992). Neurotoxicology. CRC Press. pp. 462–. ISBN 978-1-4398-0542-8.
3. Johansen CA, Mayer DF (1990). Pollinator Protection: A Bee & Pesticide Handbook. Wicwas Press. ISBN 978-1-878075-00-0.
4. Xiong J, Zhang X, Huang J, Chen C, Chen Z, Liu L, et al. (March 2016). "Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration". Molecular Neurobiology. 53 (2): 995–1008. doi:10.1007/s12035-014-9057-2. PMC 5333774. PMID 25575680.