Flavokavain A
Flavokavain A is a flavokavain found in the kava plant.[1] It induces apoptosis in bladder cancer cells via a Bax protein-dependent and mitochondria-dependent apoptotic pathway.[2]
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| Names | |
|---|---|
| IUPAC name
(E)-3-(4-methoxyphenyl)-1-(2,4-bismethoxy-6-hydroxyphenyl)propenone | |
| Other names
2'-hydroxy-4,4',6'-trimethoxychalcone Flavokawain A | |
| Identifiers | |
3D model (JSmol) |
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| 2224776 | |
PubChem CID |
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| Properties | |
| C18H18O5 | |
| Molar mass | 314.337 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is  ?) | |
| Infobox references | |
See also
References
- Dharmaratne, H. Ranjith W.; N. P. Dhammika Nanayakkara; Ikhlas A. Khan (February 2002). "Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses". Phytochemistry. 59 (4): 429–33. doi:10.1016/S0031-9422(01)00443-5. PMID 11830162.
- Zi X, Simoneau AR (April 2005). "Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice". Cancer Research. 65 (8): 3479–86. doi:10.1158/0008-5472.CAN-04-3803. PMID 15833884.
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