Fusobacterium

Fusobacterium is a genus of anaerobic, Gram-negative, non-sporeforming bacteria, similar to Bacteroides. Individual cells are slender, rod-shaped bacilli with pointed ends.[2][3] Strains of Fusobacterium cause several human diseases, including periodontal diseases, Lemierre's syndrome, and topical skin ulcers.

Fusobacterium
Fusobacterium novum in liquid culture
Scientific classification
Domain: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Knorr 1922
Type species
Fusobacterium nucleatum[1]
Species

F. canifelinum[1]
F. equinum[1]
F. gonidiaformans[1]
F. mortiferum[1]
F. naviforme[1]
F. necrogenes[1]
F. necrophorum[1]
F. nucleatum[1]
F. perfoetens[1]
F. periodonticum[1]
F. russii[1]
F. simiae[1]
F. ulcerans[1]
F. varium[1]

Although older sources state that Fusobacterium is part of the normal flora of the human oropharynx, the current consensus is that Fusobacterium should always be treated as a pathogen.[4] F. prausnitzii, a gut commensal associated with healthy patients, was completely reclassified as Faecalibacterium (Clostridiales:Ruminococcaceae) in 2002.

Clinical relevance

In 2011, researchers discovered that Fusobacterium flourishes in colon cancer cells, and is often also associated with ulcerative colitis, although researchers have not determined if the organism actually causes these diseases or if it simply flourishes in the environment these diseases create.[5] The bacterium is a big anchor for biofilms.[6][7] It is susceptible to clindamycin.[8] In contrast to Bacteroides spp., Fusobacterium has a potent lipopolysaccharide.

See also

References
  1. Parte, A.C. "Fusobacterium". LPSN.
  2. Madigan M; Martinko J, eds. (2005). Brock Biology of Microorganisms (11th ed.). Prentice Hall. ISBN 978-0-13-144329-7.
  3. Taber's Cyclopedic Medical Dictionary, 22nd Edition, ISBN 9780803629790, (2009)n p.983
  4. Aliyu SH, Marriott RK, Curran MD, et al. (October 2004). "Real-time PCR investigation into the importance of Fusobacterium necrophorum as a cause of acute pharyngitis in general practice". J Med Microbiol. 53 (Pt 10): 1029–35. doi:10.1099/jmm.0.45648-0. PMID 15358827.
  5. Alice Park (18 October 2011). "A Surprising Link Between Bacteria and Colon Cancer". Time.com. Retrieved 18 October 2011.
  6. Saito, Y.; Fujii, R.; Nakagawa, K.-I.; Kuramitsu, H. K.; Okuda, K.; Ishihara, K. (February 2008). "Stimulation of Fusobacterium nucleatum biofilm formation by Porphyromonas gingivalis". Oral Microbiology and Immunology. 23 (1): 1–6. doi:10.1111/j.1399-302X.2007.00380.x. hdl:10130/821. PMID 18173791.
  7. Okuda, Tamaki; Kokubu, Eitoyo; Kawana, Tomoko; Saito, Atsushi; Okuda, Katsuji; Ishihara, Kazuyuki (Feb 2012). "Synergy in biofilm formation between Fusobacterium nucleatum and Prevotella species" (PDF). Anaerobe. 18 (1): 110–116. doi:10.1016/j.anaerobe.2011.09.003. hdl:10130/3922. ISSN 1095-8274. PMID 21945879.
  8. "Clindamycin" (PDF). Davis. 2017. Retrieved November 14, 2017.
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