GLRX3

Glutaredoxin-3 is a protein that in humans is encoded by the GLRX3 gene.[5][6][7]

GLRX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DIY, 2WZ9, 2YAN, 3ZYW
Identifiers
Aliases	GLRX3, GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3, glutaredoxin 3
External IDs	OMIM: 612754 MGI: 1353653 HomoloGene: 4769 GeneCards: GLRX3
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.3 Start 130,136,391 bp[1] End 130,184,521 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F4 Start 137,437,614 bp[2] End 137,468,594 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein disulfide oxidoreductase activity • electron transfer activity • iron-sulfur cluster binding • GO:0001948 protein binding • metal ion binding • protein kinase C binding • RNA binding • identical protein binding • glutathione disulfide oxidoreductase activity Cellular component • cytoplasm • dendrite • cell cortex • Z disc • extracellular exosome • cell nucleus • cytosol Biological process • oxidation-reduction process • cell redox homeostasis • negative regulation of cardiac muscle hypertrophy • regulation of the force of heart contraction • [2Fe-2S cluster assembly] • protein maturation by iron-sulfur cluster transfer • electron transport chain • cellular iron ion homeostasis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10539	30926
Ensembl	ENSG00000108010	ENSMUSG00000031068
UniProt	O76003	Q9CQM9
RefSeq (mRNA)	NM_001199868 NM_006541 NM_001321980	NM_023140 NM_001348093
RefSeq (protein)	NP_001186797 NP_001308909 NP_006532	NP_075629 NP_001335022
Location (UCSC)	Chr 10: 130.14 – 130.18 Mb	Chr 7: 137.44 – 137.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GLRX3 has been shown to interact with PRKCQ.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000108010 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031068 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Witte S, Villalba M, Bi K, Liu Y, Isakov N, Altman A (Feb 2000). "Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain". J Biol Chem. 275 (3): 1902–9. doi:10.1074/jbc.275.3.1902. PMID 10636891.
6. Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (Jan 2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703.
7. "Entrez Gene: TXNL2 thioredoxin-like 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• Overview of all the structural information available in the PDB for UniProt: O76003 (Human Glutaredoxin-3 (GLRX3)) at the PDBe-KB.