GPX8

Glutathione peroxidase 8 (GPx-8) is an enzyme that in humans is encoded by the GPX8 gene.[5][6] GPx-8 is a member of the glutathione peroxidase family.

GPX8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CYN, 3KIJ
Identifiers
Aliases	GPX8, EPLA847, GPx-8, GSHPx-8, UNQ847, glutathione peroxidase 8 (putative)
External IDs	OMIM: 617172 MGI: 1916840 HomoloGene: 88454 GeneCards: GPX8
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.2 Start 55,160,167 bp[1] End 55,167,297 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D2.2 Start 113,042,753 bp[2] End 113,046,410 bp[2]
Gene ontology Molecular function • oxidoreductase activity • glutathione peroxidase activity • peroxidase activity Cellular component • integral component of membrane • endoplasmic reticulum lumen • membrane Biological process • oxidation-reduction process • response to oxidative stress • cellular oxidant detoxification • cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	493869	69590
Ensembl	ENSG00000164294	ENSMUSG00000021760
UniProt	Q8TED1	Q9D7B7
RefSeq (mRNA)	NM_001008397 NM_001306197 NM_001306198 NM_001306201	NM_027127
RefSeq (protein)	NP_001008398 NP_001293126 NP_001293127 NP_001293130	NP_081403
Location (UCSC)	Chr 5: 55.16 – 55.17 Mb	Chr 13: 113.04 – 113.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Glutathione Peroxidase 8 (GPX8)

References

1. GRCh38: Ensembl release 89: ENSG00000164294 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021760 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: glutathione peroxidase 8 (putative)".
6. Toppo S, Vanin S, Bosello V, Tosatto SC (September 2008). "Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily". Antioxid. Redox Signal. 10 (9): 1501–14. doi:10.1089/ars.2008.2057. PMID 18498225.