GTPase-activator protein for Ras-like GTPase

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1nf1A:1256-1451 1wer :769-942 1wq1G:769-942

GTPase-activator protein for Ras-like GTPase
Identifiers
Symbol	RasGAP
Pfam	PF00616
InterPro	IPR001936
SMART	RasGAP
SCOP2	1wer / SCOPe / SUPFAM
CDD	cd04519
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1nf1A:1256-1451 1wer :769-942 1wq1G:769-942

GTPase-activator protein for Ras-like GTPase is a family of evolutionarily related proteins.

Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP.[1] This intrinsic GTPase activity of ras is stimulated by a family of proteins collectively known as 'GAP' or GTPase-activating proteins.[2][3] As it is the GTP bound form of ras which is active, these proteins are said to be down-regulators of ras.

The Ras GTPase-activating proteins are quite large (from 765 residues for sar1 to 3079 residues for IRA2) but share only a limited (about 250 residues) region of sequence similarity, referred to as the 'catalytic domain' or rasGAP domain.

Note: There are distinctly different GAPs for the rap and rho/rac subfamilies of ras-like proteins (reviewed in reference[4]) that do not share sequence similarity with ras GAPs.

Examples

Human genes encoding proteins containing this domain include:

DAB2IP;
GAPVD1;
IQGAP1; IQGAP2; IQGAP3;
NF1;
RASA1; RASA2; RASA3; RASA4; RASAL1; RASAL2;
SYNGAP1;

References

McCormick F, Bourne HR, Sanders DA (1991). "The GTPase superfamily: conserved structure and molecular mechanism". Nature. 349 (6305): 117–127. Bibcode:1991Natur.349..117B. doi:10.1038/349117a0. PMID 1898771. S2CID 4349901.
Wang Y, Riggs M, Rodgers L, Wigler M, Boguski M (1991). "sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1". Cell Regul. 2 (6): 453–465. doi:10.1091/mbc.2.6.453. PMC 361829. PMID 1883874.
Maruta H, Burgess AW (1994). "Regulation of the Ras signalling network". BioEssays. 16 (7): 489–496. doi:10.1002/bies.950160708. PMID 7945277. S2CID 22850138.
McCormick F, Boguski MS (1993). "Proteins regulating Ras and its relatives". Nature. 366 (6456): 643–654. Bibcode:1993Natur.366..643B. doi:10.1038/366643a0. PMID 8259209. S2CID 4338237.

This article incorporates text from the public domain Pfam and InterPro: IPR001936

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[PUB00004087-1] McCormick F, Bourne HR, Sanders DA (1991). "The GTPase superfamily: conserved structure and molecular mechanism". Nature. 349 (6305): 117–127. Bibcode:1991Natur.349..117B. doi:10.1038/349117a0. PMID 1898771. S2CID 4349901.

[PUB00000983-2] Wang Y, Riggs M, Rodgers L, Wigler M, Boguski M (1991). "sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1". Cell Regul. 2 (6): 453–465. doi:10.1091/mbc.2.6.453. PMC 361829. PMID 1883874.

[PUB00000726-3] Maruta H, Burgess AW (1994). "Regulation of the Ras signalling network". BioEssays. 16 (7): 489–496. doi:10.1002/bies.950160708. PMID 7945277. S2CID 22850138.

[PUB00004162-4] McCormick F, Boguski MS (1993). "Proteins regulating Ras and its relatives". Nature. 366 (6456): 643–654. Bibcode:1993Natur.366..643B. doi:10.1038/366643a0. PMID 8259209. S2CID 4338237.