GW0742

GW0742 (also known as GW610742) is a PPARδ/β agonist[2][3][4] that is investigated for drug use by GlaxoSmithKline.[5]

GW0742

Clinical data
ATC code	None
Legal status
Legal status	Investigational
Identifiers
IUPAC name [4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methyl phenoxy]-acetic acid[1]
CAS Number	317318-84-6
PubChem CID	9934458
IUPHAR/BPS	2686
ChemSpider	8110086
KEGG	C15625
ChEMBL	ChEMBL38508
CompTox Dashboard (EPA)	DTXSID9040760
Chemical and physical data
Formula	C21H17F4NO3S2
Molar mass	471.48 g·mol^−1
3D model (JSmol)	Interactive image
SMILES FC(F)(F)c3c(F)cc(c1nc(c(s1)CSc2cc(c(OCC(=O)O)cc2)C)C)cc3
InChI InChI=InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28) Key:HWVNEWGKWRGSRK-UHFFFAOYSA-N

See also

• GW501516
• Elafibranor
• Peroxisome proliferator-activated receptor

References

1. "Cayman Chemical GW0742". Retrieved 31 Mar 2013.
2. Smith SA, Monteith GR, Robinson JA, Venkata NG, May FJ, Roberts-Thomson SJ (July 2004). "Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons". Journal of Neuroscience Research. 77 (2): 240–9. doi:10.1002/jnr.20153. PMID 15211590.
3. Haskova Z, Hoang B, Luo G, Morgan LA, Billin AN, Barone FC, et al. (July 2008). "Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARbeta/delta ligand GW0742". Inflammation Research. 57 (7): 314–21. doi:10.1007/s00011-007-7157-4. PMID 18622687.
4. Sznaidman ML, Haffner CD, Maloney PR, Fivush A, Chao E, Goreham D, Sierra ML, LeGrumelec C, Xu HE, Montana VG, Lambert MH, Willson TM, Oliver WR, Sternbach DD (May 2003). "Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)--synthesis and biological activity". Bioorganic & Medicinal Chemistry Letters. 13 (9): 1517–21. doi:10.1016/s0960-894x(03)00207-5. PMID 12699745.
5. Wagner N, Jehl-Piétri C, Lopez P, Murdaca J, Giordano C, Schwartz C, et al. (July 2009). "Peroxisome proliferator-activated receptor beta stimulation induces rapid cardiac growth and angiogenesis via direct activation of calcineurin" (PDF). Cardiovascular Research. 83 (1): 61–71. doi:10.1093/cvr/cvp106. PMID 19351742.